Human Adenoviruses

From Villains to Vectors

Human adenoviruses play a central role in human diseases and as vectors for vaccines and gene delivery. This monograph describes the underlying principles of adenovirus molecular and structural biology, pathogenesis, antiviral measures and vector development. Much of the history of this virus and the many contributions made by its study are embedded in these discussions. Topics and questions that require further investigation are also considered.

Although current virology textbooks cover topics related to adenoviruses, this book provides a comprehensive description of the virus and its interactions with the host. Students and researchers with a particular interest in adenoviruses, gene therapists, and virologists interested in viral pathogenesis will benefit from this book, which presents a unique integration of the basics with applied research in the field.

Contents:

• A Short History of Adenovirus
• Adenovirus Composition, Structure, and Biophysical Properties
• Cell Attachment and Entry
• Intracellular Trafficking
• Gene Expression
• Replication of the Genome
• Capsid Assembly, Maturation, and Egress
• Pathogenesis
• Host Defenses
• Antiviral Approaches
• Therapeutic Applications: History and Use of Replication-Defective Vectors
• Therapeutic Applications: Vaccines and Oncolytic Vectors

Readership: Graduate students and researchers interested in adenoviruses, gene therapists, and virologists.
Key Features:

• The only up-to-date book devoted strictly to adenoviruses
• Covers a wide diversity of basic and applied topics relating to adenoviruses