The Rho GTPases in Cancer

Nonfiction, Science & Nature, Science, Other Sciences, Molecular Biology, Health & Well Being, Medical, Specialties, Oncology
Cover of the book The Rho GTPases in Cancer by , Springer New York
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781441911117
Publisher: Springer New York Publication: December 4, 2009
Imprint: Springer Language: English
Author:
ISBN: 9781441911117
Publisher: Springer New York
Publication: December 4, 2009
Imprint: Springer
Language: English

Channing Der and colleagues provide an encyclopedic overview of the Rho GTPases, providing enough detail to make any reader well-versed in the Rho field. Finally, Sofia Merajver’s laboratory provides an overview, which details the roles of the Rho proteins in cancer progression. She provides us with the history of the study of the Rho GTPases, their regulatory and effector proteins in cancer and gives us a benchmark of where the field is today. The second section of the book details the current knowledge of the Rho regu- tory proteins in cancer progression: aberrant expression and activation of these proteins leads to dysfunctional Rho signaling and a cancer phenotype. Gary Bokoch’s laboratory has provided a detailed overview of the role of Rho guanine dissociation inhibitors (GDIs) in cancer. These molecules are involved in preventing the Rho protein from associating with the inner plasma membrane and exchanging GDP for GTP, and thus becoming active. Next, Tozu Kazasa’s labo- tory has worked on the link between heterotrimeric G proteins and Rho activation via the RGS–RhoGEFs. This aspect of Rho activation is particularly interesting in that heterotrimeric G proteins and their associated G-protein-coupled receptors are attractive and attainable therapeutic targets. Dan Billadeau’s laboratory has worked extensively on the Vav RhoGEFs, which are potent oncogenes in their own right.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Channing Der and colleagues provide an encyclopedic overview of the Rho GTPases, providing enough detail to make any reader well-versed in the Rho field. Finally, Sofia Merajver’s laboratory provides an overview, which details the roles of the Rho proteins in cancer progression. She provides us with the history of the study of the Rho GTPases, their regulatory and effector proteins in cancer and gives us a benchmark of where the field is today. The second section of the book details the current knowledge of the Rho regu- tory proteins in cancer progression: aberrant expression and activation of these proteins leads to dysfunctional Rho signaling and a cancer phenotype. Gary Bokoch’s laboratory has provided a detailed overview of the role of Rho guanine dissociation inhibitors (GDIs) in cancer. These molecules are involved in preventing the Rho protein from associating with the inner plasma membrane and exchanging GDP for GTP, and thus becoming active. Next, Tozu Kazasa’s labo- tory has worked on the link between heterotrimeric G proteins and Rho activation via the RGS–RhoGEFs. This aspect of Rho activation is particularly interesting in that heterotrimeric G proteins and their associated G-protein-coupled receptors are attractive and attainable therapeutic targets. Dan Billadeau’s laboratory has worked extensively on the Vav RhoGEFs, which are potent oncogenes in their own right.

More books from Springer New York

Cover of the book Microbial Food Safety by
Cover of the book Natural Convection in Superposed Fluid-Porous Layers by
Cover of the book Perinatal Programming of Neurodevelopment by
Cover of the book The Genetics and Development of Scoliosis by
Cover of the book Mitochondria and Cancer by
Cover of the book Single-molecule Studies of Proteins by
Cover of the book Handbook of Identity Theory and Research by
Cover of the book System Specification and Design Languages by
Cover of the book Residue Reviews by
Cover of the book Geropsychology and Long Term Care by
Cover of the book Sterile Product Development by
Cover of the book The Witness Stand and Lawrence S. Wrightsman, Jr. by
Cover of the book Embedded Memory Design for Multi-Core and Systems on Chip by
Cover of the book Microdroplet Technology by
Cover of the book Learning Analytics by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy