Skeletal Circulation in Clinical Practice

Bone circulation is important to our understanding of many major orthopedic conditions such as osteoarthritis, osteoporosis, repair, and tumors. Yet, circulatory physiology, basic to all healthy organs and most diseases, has been difficult to study in the skeleton. The biological regulation of blood flow is complex and the tissues have been relatively inaccessible to measurement. In recent years, however, advances have been made in understanding circulatory physiology and fluid flow in bone, functional measurement of blood flow, and the roles of circulation in bone turnover and repair. These advances have enhanced our insights into bone homeostasis and the interrelationships of circulation and skeletal biology, including repair and disease.

This seminal volume presents updated information on circulatory physiology of bone and fluid flow through the bone matrix. It then describes new techniques in quantifying and imaging bone circulation. A clinical section covering circulatory elements of skeletal diseases provides valuable insight into pathophysiology that may serve as diagnostic biomarkers or therapeutic targets.

Contents:

• Physiology:

  • The Physiology of Bone Circulation (Ian McCarthy & Ines Reichert)
  • Molecular Transport in Musculoskeletal Health and Disease (Melissa L Knothe Tate, Roy K Aaron, Anita Ignatius, Lutz Dürselen and Stan Rockson)

• Techniques of Measurement of Bone Circulation:

  • The Microsphere Method for Investigating Bone Blood Flow (Hermann Anetzberger and Christof Birkenmaier)
  • Laser Doppler Flowmetry (Seth O'Donnell, Scott Ritterman and Lee Rubin)
  • Engineering and Clinical Aspects of Photoplethysmography (Roy K Aaron, Oussama Fadil, Jennifer Racine and Domenico Pacifici)
  • MRI and PET (Jonathan P Dyke)

• Pathophysiology of Skeletal Circulation:

  • Circulatory Pathology in Osteonecrosis (Lynne C Jones and Roy K Aaron)
  • Osteonecrosis in Patients with Sickle Cell Anemia and Other Hematologic Disorders (Luke M Vaughan, Sarah A Long, Thomas Santamaría, Marc J Kahn, Josephina A Vossen, Miriam A Bredella, Alan L Schiller and Henry J Mankin)
  • Fractures and Bone Repair (Dean G Lorich and Lionel E Lazaro)
  • Joint Inflammation and Synovitis (Alissa J Burge)
  • Circulatory Pathology in Osteoarthritis (Roy K Aaron)
  • Osteoporosis, Circulation, and Fluid Dynamics (Bing Zang, Jaime Mateus and Alan Hargens)
  • Circulation of the Pediatric and Adolescent Hip (Jeremy Doak, Jonathan Schiller and Craig Eberson)

Readership: Orthopedic surgeons and researchers, bone specialists, osteopathologists, musculoskeletal researchers, arthritis and osteoporosis researchers.
Key Features:

• It is comprehensive
• Contemporary up to date information with innovative insights into pathophysiology
• Internationally recognized experts in their respective fields as authors