Poorly Soluble Drugs

Dissolution and Drug Release

Nonfiction, Science & Nature, Science, Chemistry, Analytic, Health & Well Being, Medical, Specialties, Pharmacy, Medical Science, Pharmacology
Cover of the book Poorly Soluble Drugs by Gregory K. Webster, Robert G. Bell, J. Derek Jackson, Jenny Stanford Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Gregory K. Webster, Robert G. Bell, J. Derek Jackson ISBN: 9781315340869
Publisher: Jenny Stanford Publishing Publication: January 6, 2017
Imprint: Jenny Stanford Publishing Language: English
Author: Gregory K. Webster, Robert G. Bell, J. Derek Jackson
ISBN: 9781315340869
Publisher: Jenny Stanford Publishing
Publication: January 6, 2017
Imprint: Jenny Stanford Publishing
Language: English

This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-à-vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development.

Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-à-vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development.

Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.

More books from Jenny Stanford Publishing

Cover of the book Handbook of Textile Effluent Remediation by Gregory K. Webster, Robert G. Bell, J. Derek Jackson
Cover of the book Sparks from the Spirit by Gregory K. Webster, Robert G. Bell, J. Derek Jackson
Cover of the book Self-Assembled Organic-Inorganic Nanostructures by Gregory K. Webster, Robert G. Bell, J. Derek Jackson
Cover of the book Nanomaterials for Direct Alcohol Fuel Cell by Gregory K. Webster, Robert G. Bell, J. Derek Jackson
Cover of the book How to Attract Investors by Gregory K. Webster, Robert G. Bell, J. Derek Jackson
Cover of the book Marine Polysaccharides by Gregory K. Webster, Robert G. Bell, J. Derek Jackson
Cover of the book Pulsed Laser Ablation by Gregory K. Webster, Robert G. Bell, J. Derek Jackson
Cover of the book Tissue Phenomics: Profiling Cancer Patients for Treatment Decisions by Gregory K. Webster, Robert G. Bell, J. Derek Jackson
Cover of the book Functional Nanostructured Membranes by Gregory K. Webster, Robert G. Bell, J. Derek Jackson
Cover of the book Quantum Physics for Beginners by Gregory K. Webster, Robert G. Bell, J. Derek Jackson
Cover of the book Nanotechnology and Energy by Gregory K. Webster, Robert G. Bell, J. Derek Jackson
Cover of the book DNA Engineering by Gregory K. Webster, Robert G. Bell, J. Derek Jackson
Cover of the book Gallium Nitride Power Devices by Gregory K. Webster, Robert G. Bell, J. Derek Jackson
Cover of the book Spin Chemical Physics of Graphene by Gregory K. Webster, Robert G. Bell, J. Derek Jackson
Cover of the book Biocomposites by Gregory K. Webster, Robert G. Bell, J. Derek Jackson
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy