Oral Bioavailability Assessment
Basics and Strategies for Drug Discovery and Development
Nonfiction, Science & Nature, Science, Chemistry, Analytic, Health & Well Being, Medical, Medical Science, Pharmacology
| Author: | Ayman F. El-Kattan, Mike S. Lee | ISBN: | 9781118916933 |
| Publisher: | Wiley | Publication: | May 15, 2017 |
| Imprint: | Wiley | Language: | English |
| Author: | Ayman F. El-Kattan, Mike S. Lee |
| ISBN: | 9781118916933 |
| Publisher: | Wiley |
| Publication: | May 15, 2017 |
| Imprint: | Wiley |
| Language: | English |
Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.
• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
• Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
• Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
• Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
• Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development
Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.
• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
• Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
• Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
• Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
• Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development
