Molecular Targets in Protein Misfolding and Neurodegenerative Disease
Nonfiction, Science & Nature, Science, Other Sciences, Molecular Biology, Biological Sciences, Health & Well Being, Medical
| Author: | Pierfausto Seneci | ISBN: | 9780128004999 |
| Publisher: | Elsevier Science | Publication: | October 7, 2014 |
| Imprint: | Academic Press | Language: | English |
| Author: | Pierfausto Seneci |
| ISBN: | 9780128004999 |
| Publisher: | Elsevier Science |
| Publication: | October 7, 2014 |
| Imprint: | Academic Press |
| Language: | English |
Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc.
- Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases
- Provides a “drug discovery application oriented perspective, evaluating targets and candidates for their overall therapeutic potential
- Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development
- Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area
- Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets
Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc.
- Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases
- Provides a “drug discovery application oriented perspective, evaluating targets and candidates for their overall therapeutic potential
- Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development
- Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area
- Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets
