Estrogen Action, Selective Estrogen Receptor Modulators and Women's Health

Progress and Promise

This volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs — tamoxifen and raloxifene — are known to have saved the lives of millions of women around the world and improved the health of millions more. Estrogen is the central hormone of women's health and reproduction. The book is a journey through 40 years of discovery and success in advancing women's health, with the prospect of improved innovation through medicinal chemistry for the future.

Contents:

• A Century of Deciphering the Control Mechanisms of Estrogen Action in Breast Cancer: The Origins of Targeted Therapy and Chemoprevention (V Craig Jordan)
• Diethylstilbestrol: A Tragedy in Reproductive Endocrinology But a Pioneering Cancer Treatment (Joan Lewis-Wambi and V Craig Jordan)
• Oral Contraceptives and Women's Health (V Daniel Castracane and V Craig Jordan)
• Hormone Replacement Therapy and Women's Health (Jennifer Eng-Wong, Ifeyinwa Obiorah and V Craig Jordan)
• Induction of Ovulation by Nonsteroidal Antiestrogens (Ifeyinwa Obiorah and V Craig Jordan)
• Clues About Estrogen and Antiestrogen Action from X-Ray Crystallography (Geoffrey L Greene and V Craig Jordan)
• Coregulators and Their Role in Selective Estrogen Receptor Modulator Action (Christopher D Chien, Anton Wellstein and Anna Riegel)
• Role of Estrogen in Familial Breast Cancer (Eliot Rosen and Claudine Isaacs)
• Advances with Aromatase Inhibitors (Saranya Chumsri, Ting Bao, Gauri Sabnis and Angela Brodie)
• Adjuvant Antihormone Therapy (Anthony Howell and V Craig Jordan)
• Pharmacogenomics of Tamoxifen (Hiltrud B Brauch and V Craig Jordan)
• Antihormone Drug Resistance (Robert Clarke and V Craig Jordan)
• Novel Selective Estrogen Receptor Modulators (Surojeet Sengupta and V Craig Jordan)
• Endocrine Prevention of Breast Cancer (Trevor J Powles, Russell E McDaniel and V Craig Jordan)
• Selective Androgen Receptor Modulators as Improved Androgen Therapy for Women (Christopher C Coss and James T Dalton)
• An Emerging Principle: Selective Nuclear Receptor Modulators (Ping Fan and V Craig Jordan)

Readership: Clinicians, biological faculty, informed patients, scientists and students in biology and medicine, healthcare and medical professionals, breast cancer survivors.
Key Features:

• A unique easy-to-read book for clinicians, biological faculty, informed patients, scientists and medical professionals
• Focuses on the evolution of estrogen action in women's health and changes in healthcare through scientific research
• A concise summary of progress
• No other competing titles of the same caliber
• Written by the pioneers in the field