Cushing’s Syndrome

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Endocrinology & Metabolism
Cover of the book Cushing’s Syndrome by D. T. Krieger, Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: D. T. Krieger ISBN: 9783642816598
Publisher: Springer Berlin Heidelberg Publication: December 6, 2012
Imprint: Springer Language: English
Author: D. T. Krieger
ISBN: 9783642816598
Publisher: Springer Berlin Heidelberg
Publication: December 6, 2012
Imprint: Springer
Language: English

The unraveling of our knowledge of the functions of the adrenal gland constitutes one exciting development of modern medicine and biochemistry. We owe these advances to the felicitous cooperative efforts of the clinical investigator and the biochemist. Three centuries elapsed between the first recorded anatomical descrip­ tion of the adrenals and the demonstration by Dr. Addison in the mid-nineteenth century of the fatal results of the destruction of these glands by disease. It became evident from this observation that the adrenals secreted a "factor" or "factors" essential to life. It took approximately 90 years to isolate this elusive vital factor - cortisone - from beef adrenal cortices, independently by both Reichstein and his co-workers in Basle and Kendall and his group in the United States and another 10-15 years before it became more generally available for experimental and clinical use. It is perhaps difficult to believe that as recently as 35-40 years ago, before cortisone and cortisol were clinically available, the surgical removal of a benign adrenal cortical tumor in patients with Cushing's syndrome was associated with a prohibitive postoperative mortality rate. Within 12-36 h after operation, most of such patients developed an intractable state of shock, which was not manifested by significant electrolyte abnormalities or hypoglycemia and was unresponsive to the usual treatment for shock plus the generous use of salt-retaining hormone.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The unraveling of our knowledge of the functions of the adrenal gland constitutes one exciting development of modern medicine and biochemistry. We owe these advances to the felicitous cooperative efforts of the clinical investigator and the biochemist. Three centuries elapsed between the first recorded anatomical descrip­ tion of the adrenals and the demonstration by Dr. Addison in the mid-nineteenth century of the fatal results of the destruction of these glands by disease. It became evident from this observation that the adrenals secreted a "factor" or "factors" essential to life. It took approximately 90 years to isolate this elusive vital factor - cortisone - from beef adrenal cortices, independently by both Reichstein and his co-workers in Basle and Kendall and his group in the United States and another 10-15 years before it became more generally available for experimental and clinical use. It is perhaps difficult to believe that as recently as 35-40 years ago, before cortisone and cortisol were clinically available, the surgical removal of a benign adrenal cortical tumor in patients with Cushing's syndrome was associated with a prohibitive postoperative mortality rate. Within 12-36 h after operation, most of such patients developed an intractable state of shock, which was not manifested by significant electrolyte abnormalities or hypoglycemia and was unresponsive to the usual treatment for shock plus the generous use of salt-retaining hormone.

More books from Springer Berlin Heidelberg

Cover of the book The Impact of International Trade and FDI on Economic Growth and Technological Change by D. T. Krieger
Cover of the book Carbon Sequestration in the Biosphere by D. T. Krieger
Cover of the book Explosive Percolation in Random Networks by D. T. Krieger
Cover of the book The Meniscus by D. T. Krieger
Cover of the book NanoCarbon 2011 by D. T. Krieger
Cover of the book Hormone Toxicity in the Newborn by D. T. Krieger
Cover of the book Clinical Review of Vascular Trauma by D. T. Krieger
Cover of the book Computational Modeling in Tissue Engineering by D. T. Krieger
Cover of the book Soils of Tropical Forest Ecosystems by D. T. Krieger
Cover of the book Proteopathic Seeds and Neurodegenerative Diseases by D. T. Krieger
Cover of the book Muscle Pain: Diagnosis and Treatment by D. T. Krieger
Cover of the book New Concepts in Diagnosis and Therapy of Pancreatic Adenocarcinoma by D. T. Krieger
Cover of the book Baustoff und Konstruktion by D. T. Krieger
Cover of the book Arachidonic Acid in Cell Signaling by D. T. Krieger
Cover of the book Disposable Bioreactors II by D. T. Krieger
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy