Compendium of In Vivo Monitoring in Real-Time Molecular Neuroscience

Volume 1: Fundamentals and Applications

This new volume documents the transition from the development of electrochemical monitoring of brain function, now more than 40 years old, to fundamental neuroscience. This includes the links of molecular neuroscience to biobehavior, to a molecular understanding of neurologically-linked diseases and to the investigation of neuroactive molecules made possible by new detection methodology. This work should be of interest to a broad audience, especially those who are engaged in neuroscience research, for example in drug discovery, but are not familiar with electrochemical methodology.

Contents:

• Using Biosensors to Probe Fundamental Questions of Sleep (Erik Naylor and Peter A Petillo)
• Cortical Cholinergic Transients for Cue Detection and Attentional Mode Shifts (Martin Sarter, William M Howe and Howard Gritton)
• Real-Time Measurement of ATP and Adenosine in the Nervous System (Nicholas Dale)
• Electrochemical Detection of Adenosine In Vivo (Ashley E Ross and B Jill Venton)
• Real-Time In Vivo Neurotransmitter Measurements Using Enzyme-Based Ceramic Microelectrode Arrays: What We Have Learned About Glutamate Signaling (Jason J Burmeister, Erin R Hascup, Kevin N Hascup, Verda Davis, Seth R Batten, Francois Pomerleau, Jorge E Quintero, Peter Huettl, Pooja M Talauliker, Ingrid Strömberg, Greg A Gerhardt)
• Enzyme-Based Microbiosensors for Selective Quantification of Rapid Molecular Fluctuations in Brain Tissue (Leyda Z Lugo-Morales and Leslie A Sombers)
• Monitoring and Modulating Dopamine Release and Unit Activity in Real-Time (Anna M Belle and R Mark Wightman)
• Quantitative Chemical Measurements of Vesicular Transmitters with Single Cell Amperometry and Electrochemical Cytometry (Jelena Lovrić, Xianchan Li, Andrew G Ewing)
• Coupling Voltammetry with Optogenetics to Reveal Axonal Control of Dopamine Transmission by Striatal Acetylcholine (Polina Kosillo, Katherine R Brimblecombe, Sarah Threlfell and Stephanie J Cragg)
• Electrochemical Recordings During Deep Brain Stimulation in Animals and Humans: WINCS, MINCS, and Closed Loops DBS (Charles D Blaha, Su-Youne Chang, Kevin E Bennet and Kendall H Lee)
• Sweet Leaf: Neurochemical Advances Reveal How Cannabinoids Affect Brain Dopamine Concentrations (Erik B Oleson and Joseph F Cheer)
• Probing Serotonin Neurotransmission: Implications for Neuropsychiatric Disorders (Kevin M Wood, David Cepeda and Parastoo Hashemi)
• Voltammetric Analysis of Loss and Gain of Dopamine Function (Paul A Garris, Kristen A Keefe)
• Measurements of Dopamine Release and Uptake in Huntington's Disease Model Rodents (Sam V Kaplan, Stephen C Fowler, and Michael A Johnson)
• Characterizing Neuropeptide Release: From Isolated Cells to Intact Animals (Agatha E Maki and Jonathan V Sweedler)
• Advancing Chronic Intracortical Electrode Recording Function (Lohitash Karumbaiah, Tarun Saxena, and Ravi Bellamkonda)
• Measurement of Cytokines in the Brain (Julie A Stenken and Michael Elkins)

Readership: Students and researchers in neuroscience research, drug discovery, electrochemistry, neurology, neurobiology, biomedical engineering and analytical chemistry.
Key Features:

• Prior competing books were focused on the technology. Our book instead focuses on new scientific findings that the technology has delivered to the field of molecular neuroscience.