David Thurston: 11 books
Peptide-based Drug Discovery
Challenges and New Therapeutics
Language: English
Release Date: June 22, 2017
With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies.
What does...
Anti-aging Drugs
From Basic Research to Clinical Practice
Language: English
Release Date: January 18, 2017
Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular...
Antibiotic Drug Discovery
New Targets and Molecular Entities
Language: English
Release Date: May 19, 2017
Recent years have seen a resurgence of antibiotic drug discovery. This book brings together the relevant information to assess the state-of-the-art. It identifies and elaborates the most recent and compelling strategies for antibiotic drug discovery with a primary focus on new targets, mechanisms...
Cardiovascular and Metabolic Disease
Scientific Discoveries and New Therapies
Language: English
Release Date: May 18, 2015
Cardiovascular and metabolic diseases remain the number one cause of death in developed countries and their prevalence is increasing rapidly in developing nations. This book brings together the recent information on these disorders and the links that exist between them in order to provide a complete...
by Harren Jhoti, Martin Drysdale, Daniel A Erlanson
Language: English
Release Date: June 17, 2015
Language: English
Release Date: June 17, 2015
Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is...
by Jorge Alvar, Charles Mowdray, Fabiana Alves
Language: English
Release Date: October 26, 2017
Language: English
Release Date: October 26, 2017
For human health, leishmaniasis is among the most important protozoan diseases, superseded only by malaria. Globally, 10 to 12 million people are infected with 1.5 million new cases every year. The development of cheaper new drugs is urgently needed for this neglected disease that is developing resistance...
Acute Brain Impairment
Scientific Discoveries and Translational Research
Language: English
Release Date: November 17, 2017
A rise in the number of young and old patients suffering from a stroke or traumatic brain injury has led to the need for better drug development and treatment, as well as diagnosis and prevention of ischemic stroke and traumatic brain injury. This book provides a comprehensive overview of scientific...
by Andrew Scott, Mari Jean Eggen, Juan Felix Espinosa
Language: English
Release Date: November 14, 2017
Language: English
Release Date: November 14, 2017
Biophysical techniques are used in many key stages of the drug discovery process including in screening for new receptor ligands, in characterising drug mechanisms, and in validating data from biochemical and cellular assays.
This book provides an overview of the biophysical methods applied in drug...
Venoms to Drugs
Venom as a Source for the Development of Human Therapeutics
Language: English
Release Date: January 27, 2015
The pharmaceutical industry has become increasingly interested in biologics from animal venoms as a potential source for therapeutic agents in recent years, with a particularly emphasis on peptides. To date six drugs derived from venom peptides or proteins have been approved by the FDA, with nine...
Traditional Chinese Medicine
Scientific Basis for Its Use
Language: English
Release Date: October 20, 2015
Traditional Chinese medicine has a strong scientific basis, but the science of these important preparations is often rarely discussed. Western approaches often simplify traditional Chinese medicine to drug discovery in Chinese plants, however, the majority of traditional Chinese medications use complex...
Indigenous Homelessness
Perspectives from Canada, Australia, and New Zealand
Language: English
Release Date: October 28, 2016
Being homeless in one’s homeland is a colonial legacy for many Indigenous people in settler societies. The construction of Commonwealth nation-states from colonial settler societies depended on the dispossession of Indigenous peoples from their lands. The legacy of that dispossession and related...