Biophysics and Biochemistry of Protein Aggregation

Experimental and Theoretical Studies on Folding, Misfolding, and Self-Assembly of Amyloidogenic Peptides

This book reviews current research on the important processes involved in neurodegenerative diseases (e.g. Alzheimer's disease) and the peptides and proteins involved in the amyloidogenic processes. It covers the design and developments of anti-amyloid inhibitors, and gives readers a fundamental understanding of the underlying oligomerization and aggregation processes of these diseases from both computational and experimental points of view.

Contents:

• Preface
• Perplexity of Amyloid β-Protein Oligomer Formation: Relevance to Alzheimer's Disease*(Brigita Urbanc)*
• Exploring the Aggregation Mechanism of Intrinsically Disordered Tau Protein (Ruxi Qi, Guanghong Wei, Ruth Nussinov and Buyang Ma)
• Design and Application of Anti-Amyloid Peptide-Based Inhibitors as a Therapeutic Strategy of Alzheimer's Disease (Rita P-Y Chen)
• Statistical Mechanics and Kinetics of Amyloid Fibrillation (Liu Hong, Chiu Fan Lee and Ya Jing Huang)
• Kinetic Studies of Protein Aggregation With and Without the Presence of Crowders (John S Schreck, John Bridstrup and Jian-Min Yuan)
• Thermodynamics and Kinetics of Protein Folding and Aggregation (Min-Yeh Tsai, Jian-Min Yuan and Sheng Hsien Lin)
• Folding and Misfolding of Amyloid-β40 and 42 in Alzheimer's Disease (Yu-Jen Chang and Yun-Ru Chen)
• Single-Molecule Fluorescence Resonance Energy Transfer Studies of β-Amyloid Clusters in Physiological Solutions (Jun Han, Erwen Mei, Mei-Ping Kung, Hank F Kung, Jian-Min Yuan and Hai-Lung Dai)

Readership: Graduate students and researchers studying the field of neurodegnerative diseases and interested in the chemical processes that occur.
Key Features:

• Written by practicing experts in the field
• Provides the most up-to-date information of research in the field
• Both experimental and computational perspectives are covered