Thymic Development and Selection of T Lymphocytes

Nonfiction, Health & Well Being, Medical, Medical Science, Immunology, Physiology
Cover of the book Thymic Development and Selection of T Lymphocytes by , Springer Berlin Heidelberg
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Author: ISBN: 9783642402524
Publisher: Springer Berlin Heidelberg Publication: November 6, 2013
Imprint: Springer Language: English
Author:
ISBN: 9783642402524
Publisher: Springer Berlin Heidelberg
Publication: November 6, 2013
Imprint: Springer
Language: English

The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.

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The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.

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