Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs

Nonfiction, Health & Well Being, Medical, Ailments & Diseases, Infectious Diseases, General, Medical Science, Pharmacology
Cover of the book Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs by , Springer Singapore
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Author: ISBN: 9789811021138
Publisher: Springer Singapore Publication: December 21, 2016
Imprint: Adis Language: English
Author:
ISBN: 9789811021138
Publisher: Springer Singapore
Publication: December 21, 2016
Imprint: Adis
Language: English

Clinically-focussed, with easily accessible tables and chapter summaries suitable for clinicians and researchers,  this comprehensive book provides a systematic, critical evaluation of the current literature. An updated clinical decision-making algorithm specifically tailored to the antiretroviral drugs is also provided. The identified interactions are interpreted in the context of known mechanisms derived from clinical, preclinical, and in vitro data. The clinical relevance of the interactions is systematically evaluated and gaps in literature discussed in the context of potential future experiments. In addition to the comprehensive summary of pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antiretroviral drugs on the market today (i.e. nucleotide reverse-transcriptase inhibitors, non-nucleoside reverse-transcriptase inhibitors, integrase inhibitors, and protease inhibitors), this book also provides detailed section summaries on the epidemiology of HIV infection, diagnosis and pharmacotherapy, basic pharmacology of the individual antiretrovirals, pertinent pre-clinical and in vitro molecular pharmacology, and in vitro drug interaction data available in the literature today. 

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Clinically-focussed, with easily accessible tables and chapter summaries suitable for clinicians and researchers,  this comprehensive book provides a systematic, critical evaluation of the current literature. An updated clinical decision-making algorithm specifically tailored to the antiretroviral drugs is also provided. The identified interactions are interpreted in the context of known mechanisms derived from clinical, preclinical, and in vitro data. The clinical relevance of the interactions is systematically evaluated and gaps in literature discussed in the context of potential future experiments. In addition to the comprehensive summary of pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antiretroviral drugs on the market today (i.e. nucleotide reverse-transcriptase inhibitors, non-nucleoside reverse-transcriptase inhibitors, integrase inhibitors, and protease inhibitors), this book also provides detailed section summaries on the epidemiology of HIV infection, diagnosis and pharmacotherapy, basic pharmacology of the individual antiretrovirals, pertinent pre-clinical and in vitro molecular pharmacology, and in vitro drug interaction data available in the literature today. 

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