IGFs:Local Repair and Survival Factors Throughout Life Span

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Endocrinology & Metabolism, Medical Science, Physiology
Cover of the book IGFs:Local Repair and Survival Factors Throughout Life Span by , Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783642043024
Publisher: Springer Berlin Heidelberg Publication: December 1, 2009
Imprint: Springer Language: English
Author:
ISBN: 9783642043024
Publisher: Springer Berlin Heidelberg
Publication: December 1, 2009
Imprint: Springer
Language: English

Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.

More books from Springer Berlin Heidelberg

Cover of the book Strategic IT Management by
Cover of the book Smart Vehicle Handling - Test und Evaluation in der Fahrzeugtechnik by
Cover of the book Reconstituting the Constitution by
Cover of the book Naturschutz by
Cover of the book Late Transition Metal-Carboryne Complexes by
Cover of the book Acute Leukemias VIII by
Cover of the book Radiological, Clinical and Biomechanical Aspects of Chest Trauma by
Cover of the book Computational Multiscale Modeling of Fluids and Solids by
Cover of the book Advances in Applied Bioremediation by
Cover of the book Operative Strategies in Laparoscopic Surgery by
Cover of the book JIMD Reports, Volume 39 by
Cover of the book Star Formation in Galaxy Evolution: Connecting Numerical Models to Reality by
Cover of the book Subjective Quality Measurement of Speech by
Cover of the book Organic Solid-State Lasers by
Cover of the book Dos and Don’ts in Human Resources Management by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy