Haemostatic Drugs

A critical appraisal

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Hematology
Cover of the book Haemostatic Drugs by M. Verstraete, Springer Netherlands
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: M. Verstraete ISBN: 9789401011068
Publisher: Springer Netherlands Publication: December 6, 2012
Imprint: Springer Language: English
Author: M. Verstraete
ISBN: 9789401011068
Publisher: Springer Netherlands
Publication: December 6, 2012
Imprint: Springer
Language: English

clinical efficacy of haemostatic agents had to be published work and had to fulftl most of the following minimum requirements: (1) Quantitation ofthe measured blood loss was required, and not merely a clinical impression of the amount of blood lost, if the document pertained to a planned but «open» clinical trial. (2) Only double-blind trials with random allocation of the placebo and experimental drug to preselected patients were considered suitable for discussion, if the blood loss had not been quantitated in a prospective trial. (3) Defmition and appropriate selection of patients admitted to the trial: all inclusion and exclusion criteria used to select patients had to be mentioned in detail. (4) Once included in the trial, patients could be withdrawn only on the basis of strict criteria for withdrawal which had been defined in advance. (5) A double-blind trial had to be continued for an adequate length of time if the haemostatic agent was being assessed in the prevention of bleeding in patients with a long lasting bleeding disorder . (6) A clear and detailed statistical analysis of the results was required. Moreover, a clear distinction between the therapeutic and prophylactic value of the haemostatic agent had to be made and applied separately to the group of patients without any major basic disorder and those with a bleeding disorder e.g. : chronic thrombocytopenia, haemophilia, Rendu-Osler telangiectasia ... General statements not substantiated by experimental data, even when issued by well-known authorities, were not considered a reasonable basis for discussion.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

clinical efficacy of haemostatic agents had to be published work and had to fulftl most of the following minimum requirements: (1) Quantitation ofthe measured blood loss was required, and not merely a clinical impression of the amount of blood lost, if the document pertained to a planned but «open» clinical trial. (2) Only double-blind trials with random allocation of the placebo and experimental drug to preselected patients were considered suitable for discussion, if the blood loss had not been quantitated in a prospective trial. (3) Defmition and appropriate selection of patients admitted to the trial: all inclusion and exclusion criteria used to select patients had to be mentioned in detail. (4) Once included in the trial, patients could be withdrawn only on the basis of strict criteria for withdrawal which had been defined in advance. (5) A double-blind trial had to be continued for an adequate length of time if the haemostatic agent was being assessed in the prevention of bleeding in patients with a long lasting bleeding disorder . (6) A clear and detailed statistical analysis of the results was required. Moreover, a clear distinction between the therapeutic and prophylactic value of the haemostatic agent had to be made and applied separately to the group of patients without any major basic disorder and those with a bleeding disorder e.g. : chronic thrombocytopenia, haemophilia, Rendu-Osler telangiectasia ... General statements not substantiated by experimental data, even when issued by well-known authorities, were not considered a reasonable basis for discussion.

More books from Springer Netherlands

Cover of the book Nutrient Reduction and Biomanipulation as Tools to Improve Water Quality: The Lake Ringsjön Story by M. Verstraete
Cover of the book Learning Mathematics by M. Verstraete
Cover of the book Resilience and Risk by M. Verstraete
Cover of the book Land-Use Modelling in Planning Practice by M. Verstraete
Cover of the book The Self and The Other by M. Verstraete
Cover of the book Localizing the Moral Sense by M. Verstraete
Cover of the book Blood Pressure Control by M. Verstraete
Cover of the book Radiology of Infectious Diseases: Volume 1 by M. Verstraete
Cover of the book Development with Sustainable Use of Electricity by M. Verstraete
Cover of the book Integrating History and Philosophy of Science by M. Verstraete
Cover of the book Cerebral Monitoring in the Operating Room and the Intensive Care Unit by M. Verstraete
Cover of the book Physiological Ecology of North American Plant Communities by M. Verstraete
Cover of the book Cleavage, Connection and Conflict in Rural, Urban and Contemporary Asia by M. Verstraete
Cover of the book Geomorphological Landscapes of the World by M. Verstraete
Cover of the book A Rights-Based Preventative Approach for Psychosocial Well-being in Childhood by M. Verstraete
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy