Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells

Mathematical Modeling and Experimental Observations

Nonfiction, Science & Nature, Technology, Material Science, Computers, Advanced Computing, Computer Science
Cover of the book Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells by Iman Tavassoly, Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Iman Tavassoly ISBN: 9783319149622
Publisher: Springer International Publishing Publication: February 16, 2015
Imprint: Springer Language: English
Author: Iman Tavassoly
ISBN: 9783319149622
Publisher: Springer International Publishing
Publication: February 16, 2015
Imprint: Springer
Language: English

This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.

More books from Springer International Publishing

Cover of the book Organic Farming by Iman Tavassoly
Cover of the book Principles and Practice of Urooncology by Iman Tavassoly
Cover of the book Multifocal Intraocular Lenses by Iman Tavassoly
Cover of the book The Physics of Nuclear Reactors by Iman Tavassoly
Cover of the book A Political Theory of Post-Truth by Iman Tavassoly
Cover of the book Research Advances in the Mathematical Education of Pre-service Elementary Teachers by Iman Tavassoly
Cover of the book Challenging Islamic Orthodoxy by Iman Tavassoly
Cover of the book The Hippocampus from Cells to Systems by Iman Tavassoly
Cover of the book Cliometrics of the Family by Iman Tavassoly
Cover of the book The Integration Imperative by Iman Tavassoly
Cover of the book Earths of Distant Suns by Iman Tavassoly
Cover of the book High Impulse Voltage and Current Measurement Techniques by Iman Tavassoly
Cover of the book Purification of Peptides in High-Complexity Arrays by Iman Tavassoly
Cover of the book Encyclopedia of Analytical Surfaces by Iman Tavassoly
Cover of the book Theory and Practice of Natural Computing by Iman Tavassoly
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy