Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products

Nonfiction, Science & Nature, Science, Chemistry, Clinical, Organic
Cover of the book Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products by Taro Noguchi, Springer Singapore
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Taro Noguchi ISBN: 9789811066238
Publisher: Springer Singapore Publication: November 3, 2017
Imprint: Springer Language: English
Author: Taro Noguchi
ISBN: 9789811066238
Publisher: Springer Singapore
Publication: November 3, 2017
Imprint: Springer
Language: English

This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products. It demonstrates how, by using mirror-image proteins for the screening of available natural products, unavailable mirror-image isomers of natural products can be screened in a mirror process. Moreover, as mirror-image isomers including target proteins and natural products are mainly prepared by means of chemical synthesis, the screening strategy presented here suggests the importance of organic chemistry.

Natural products are commonly used as valuable resources for drug discovery. However, as they are mostly produced as single enantiomeric forms, researchers have tested o

nly natural products bearing one stereochemistry available in nature. As natural products and their enantiomers have identical physicochemical properties and different biological activities, mirror-image isomers of natural products are promising candidates for novel medicinal resources.

In an effort to identify anticancer agents from the mirror-image library, chemical protein syntheses of some target oncoproteins, MDM2, MDMX and Grb2, and their applications to the chemical array screening process were achieved. In the course of this process the NP843 enantiomer, which is the enantiomer of an α-tocopherol derivative, was successfully identified as a novel MDM2-p53 interaction inhibitor. These results clearly show that a mirror-image library of chiral natural products represents an invaluable medicinal resource. Accordingly, the chemistry-based screening strategy described in this thesis will be of great interest to a broad range of chemists involved in natural product, medicinal, and synthetic chemistry.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products. It demonstrates how, by using mirror-image proteins for the screening of available natural products, unavailable mirror-image isomers of natural products can be screened in a mirror process. Moreover, as mirror-image isomers including target proteins and natural products are mainly prepared by means of chemical synthesis, the screening strategy presented here suggests the importance of organic chemistry.

Natural products are commonly used as valuable resources for drug discovery. However, as they are mostly produced as single enantiomeric forms, researchers have tested o

nly natural products bearing one stereochemistry available in nature. As natural products and their enantiomers have identical physicochemical properties and different biological activities, mirror-image isomers of natural products are promising candidates for novel medicinal resources.

In an effort to identify anticancer agents from the mirror-image library, chemical protein syntheses of some target oncoproteins, MDM2, MDMX and Grb2, and their applications to the chemical array screening process were achieved. In the course of this process the NP843 enantiomer, which is the enantiomer of an α-tocopherol derivative, was successfully identified as a novel MDM2-p53 interaction inhibitor. These results clearly show that a mirror-image library of chiral natural products represents an invaluable medicinal resource. Accordingly, the chemistry-based screening strategy described in this thesis will be of great interest to a broad range of chemists involved in natural product, medicinal, and synthetic chemistry.

More books from Springer Singapore

Cover of the book Ocean Governance, Regimes, and the South China Sea Issues by Taro Noguchi
Cover of the book The Chinese National Spirit by Taro Noguchi
Cover of the book A Tutorial Introduction to VHDL Programming by Taro Noguchi
Cover of the book Digital Audio Watermarking by Taro Noguchi
Cover of the book Progress in Nanoscale Characterization and Manipulation by Taro Noguchi
Cover of the book Molecular Targeted Therapy of Lung Cancer by Taro Noguchi
Cover of the book Harmony Search Algorithm by Taro Noguchi
Cover of the book The Origin and Onset of Thrombus Disease by Taro Noguchi
Cover of the book The Test and Launch Control Technology for Launch Vehicles by Taro Noguchi
Cover of the book Media Literacy Education in China by Taro Noguchi
Cover of the book Liquid Metal Soft Machines by Taro Noguchi
Cover of the book Playable Cities by Taro Noguchi
Cover of the book The Development of Eco Cities in China by Taro Noguchi
Cover of the book Governance and Risk Management in Taxation by Taro Noguchi
Cover of the book Smart Computing and Informatics by Taro Noguchi
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy