Chemosensitivity Testing in Oncology

Nonfiction, Health & Well Being, Medical, Specialties, Oncology
Cover of the book Chemosensitivity Testing in Oncology by , Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783642190223
Publisher: Springer Berlin Heidelberg Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9783642190223
Publisher: Springer Berlin Heidelberg
Publication: December 6, 2012
Imprint: Springer
Language: English

Over the past 50 years many in vitro and in vivo drug response assay systems have been developed to determine the potential - tivity of chemotherapy agents. The idea was to eliminate ineffective agents and unnecessary toxic treatment while selecting drugs active in vitro or in the mouse model that might increase the probability of response in the patient. None of these test models, however, achieved routine clinical application in the past. This might be at least in part - lated to large discrepancies that were described between the s- cess rate of the assay systems and the clinical benefit in cancer - tients. The heterogeneity of chemosensitivity that exists between different tumors as well as between individual tumor lesions may be one explanation for these findings. Furthermore, different assay end points such as proliferation, metabolism, and vitality were - veloped to evaluate the effects of cytostatic drugs on tumor cells, and these might be related to the differing results. However, knowledge about procedures for assay-assisted treatment selection has increased rapidly within the past few years, and several studies suggest that test-directed chemotherapy selection now may - prove response rates and survival in various types of tumors. The International Society for Chemosensitivity Testing in - cology (ISCO) was founded to promote, coordinate, and improve clinical and laboratory research in the field of predictive drug te- ing in human tumor cells.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Over the past 50 years many in vitro and in vivo drug response assay systems have been developed to determine the potential - tivity of chemotherapy agents. The idea was to eliminate ineffective agents and unnecessary toxic treatment while selecting drugs active in vitro or in the mouse model that might increase the probability of response in the patient. None of these test models, however, achieved routine clinical application in the past. This might be at least in part - lated to large discrepancies that were described between the s- cess rate of the assay systems and the clinical benefit in cancer - tients. The heterogeneity of chemosensitivity that exists between different tumors as well as between individual tumor lesions may be one explanation for these findings. Furthermore, different assay end points such as proliferation, metabolism, and vitality were - veloped to evaluate the effects of cytostatic drugs on tumor cells, and these might be related to the differing results. However, knowledge about procedures for assay-assisted treatment selection has increased rapidly within the past few years, and several studies suggest that test-directed chemotherapy selection now may - prove response rates and survival in various types of tumors. The International Society for Chemosensitivity Testing in - cology (ISCO) was founded to promote, coordinate, and improve clinical and laboratory research in the field of predictive drug te- ing in human tumor cells.

More books from Springer Berlin Heidelberg

Cover of the book Cut & Paste-Management und 99 andere Neuronenstürme aus Daily Dueck by
Cover of the book Stress, Mobbing und Burn-out am Arbeitsplatz by
Cover of the book Global Risk-Based Management of Chemical Additives II by
Cover of the book Electro-Chemo-Mechanics of Anodic Porous Alumina Nano-Honeycombs: Self-Ordered Growth and Actuation by
Cover of the book A Legal Guide to United States Business Organizations by
Cover of the book Computational Studies of Transition Metal Nanoalloys by
Cover of the book Reactive Flow Modeling of Hydrothermal Systems by
Cover of the book Endocrine Treatment of Breast Cancer by
Cover of the book Maschinenelemente by
Cover of the book Dendritic Cells and Virus Infection by
Cover of the book Threats to the Quality of Groundwater Resources by
Cover of the book Integrated Computer-Aided Design in Automotive Development by
Cover of the book The History and Science of the Manhattan Project by
Cover of the book 2nd International Adalat® Symposium by
Cover of the book Medical Response to Major Incidents and Disasters by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy