Validamycin and Its Derivatives

Discovery, Chemical Synthesis, and Biological Activity

Nonfiction, Science & Nature, Science, Chemistry, Organic, Health & Well Being, Medical, Medical Science, Pharmacology
Cover of the book Validamycin and Its Derivatives by Xiaolong Chen, Yuele Lu, Yongxian Fan, Yinchu Shen, Elsevier Science
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Author: Xiaolong Chen, Yuele Lu, Yongxian Fan, Yinchu Shen ISBN: 9780081011133
Publisher: Elsevier Science Publication: March 31, 2017
Imprint: Elsevier Language: English
Author: Xiaolong Chen, Yuele Lu, Yongxian Fan, Yinchu Shen
ISBN: 9780081011133
Publisher: Elsevier Science
Publication: March 31, 2017
Imprint: Elsevier
Language: English

Validamycin and Its Derivatives: Discovery, Chemical Synthesis and Biological Activity presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds.

Beginning with an introduction to validamycin, the book then outlines the key elements of its discovery and production, including details of its structures, isolation, analysis, and issues relating to its large scale production.

Biological activities are then explored in more detail, followed by details of biosynthesis. Further to this, the chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine, and validoxylamines is reviewed, before preparation of these derivatives and their biological activities are explored.

Finally, the book concludes with a discussion of the economic aspects of working with validamycin and its potential in future applications and trends. With its detailed chemical coverage from a team of expert authors, this detailed guide can be applied to the large-scale industrial production of antibiotics and the adaptation of bioactive agents, from agricultural, to novel pharmaceutical applications.

  • Offers complete coverage of validamycin chemistry from a highly experienced team of authors
  • Encourages the discovery of further novel drugs based on validamycin derivatives
  • Presents an interesting model for establishing new pharmaceutical leads from agricultural sources
  • Includes coverage of the total chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine and validoxylamines
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Validamycin and Its Derivatives: Discovery, Chemical Synthesis and Biological Activity presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds.

Beginning with an introduction to validamycin, the book then outlines the key elements of its discovery and production, including details of its structures, isolation, analysis, and issues relating to its large scale production.

Biological activities are then explored in more detail, followed by details of biosynthesis. Further to this, the chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine, and validoxylamines is reviewed, before preparation of these derivatives and their biological activities are explored.

Finally, the book concludes with a discussion of the economic aspects of working with validamycin and its potential in future applications and trends. With its detailed chemical coverage from a team of expert authors, this detailed guide can be applied to the large-scale industrial production of antibiotics and the adaptation of bioactive agents, from agricultural, to novel pharmaceutical applications.

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