Unravelling Complexities in Genetics and Genomics

Impact on Diagnosis Counseling and Management

Unravelling Complexities in Genetics and Genomics: Impact on Diagnosis Counseling and Management reviews recent advances in defining genetic and genomic factors that play important roles in diseases in humans. It includes discussions on new technologies in DNA and RNA sequencing, genome analysis, and bioinformatics applied to the study of patients with specific disorders and to normal populations, and illustrates how modern molecular techniques can improve diagnoses and enable the design of specific targeted therapies and methods of prevention. Additional emphasis is placed on the genetic variants and genomic risk factors related to the development of complex common disorders, including neurobehavioral and neurocognitive disorders in children and adults and late onset disorders in adults, including atherosclerosis, type 2 diabetes, cancer, and neurodegenerative disorders.

Physicians, nurses, genetic counselors, graduate students in genetics and genomics will find this book a valuable read.

Contents:

• Expanding Insights into Genes and Expression
• Genomic Integrity and Relevance to Disease
• Epigenetics and Epigenomics
• Proteins, Proteomics, Protein Folding and Proteostasis
• Genotype–Phenotype Correlations and Complexities
• Immune System
• Lipids, Atherosclerosis, Metabolic Syndromes and Diabetes
• Early-Onset Neurocognitive and Neurobehavioral Disorders
• Integrating Advances in Neurobiology and Genetics into Psychiatry
• Neurodegenerative Diseases
• Cancer
• Epilogue

Readership: Physicians, nurses, genetic counselors, graduate students in genetics and genomics.
Key Features:

• Contains up-to-date information on analyses of mechanisms through which genetic and genomic factors lead to pathology and manifestations of rare and common diseases
• Includes clinical and molecular studies such as immune deficiencies, neurocognitive and neurobehavioral disorders, metabolic disorders, and malignancy