Transporters in Drug Development

Discovery, Optimization, Clinical Study and Regulation

Nonfiction, Health & Well Being, Medical, Specialties, Pharmacy, Science & Nature, Technology
Cover of the book Transporters in Drug Development by , Springer New York
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781461482291
Publisher: Springer New York Publication: September 16, 2013
Imprint: Springer Language: English
Author:
ISBN: 9781461482291
Publisher: Springer New York
Publication: September 16, 2013
Imprint: Springer
Language: English

Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.

More books from Springer New York

Cover of the book Liberating Energy from Carbon: Introduction to Decarbonization by
Cover of the book Algebraic Monoids, Group Embeddings, and Algebraic Combinatorics by
Cover of the book Systems Biology of RNA Binding Proteins by
Cover of the book Mathematics Without Boundaries by
Cover of the book Endocrine Pathology by
Cover of the book Complex Systems and Computational Biology Approaches to Acute Inflammation by
Cover of the book Autism Service Delivery by
Cover of the book Computational Methods in Elasticity and Plasticity by
Cover of the book Avoiding Treatment Failures in the Anxiety Disorders by
Cover of the book Regularity and Complexity in Dynamical Systems by
Cover of the book Community-Based Participatory Research for Improved Mental Healthcare by
Cover of the book Measure Solar System Objects and Their Movements for Yourself! by
Cover of the book Frozen Section Library: Lung by
Cover of the book Nuclear Signaling Pathways and Targeting Transcription in Cancer by
Cover of the book Resource Allocation and MIMO for 4G and Beyond by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy