Transporters in Drug Development

Discovery, Optimization, Clinical Study and Regulation

Nonfiction, Health & Well Being, Medical, Specialties, Pharmacy, Science & Nature, Technology
Cover of the book Transporters in Drug Development by , Springer New York
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781461482291
Publisher: Springer New York Publication: September 16, 2013
Imprint: Springer Language: English
Author:
ISBN: 9781461482291
Publisher: Springer New York
Publication: September 16, 2013
Imprint: Springer
Language: English

Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.

More books from Springer New York

Cover of the book Polycystic Ovary Syndrome by
Cover of the book Algebraic Topology by
Cover of the book Child Maltreatment and the Law by
Cover of the book Biomaterials Associated Infection by
Cover of the book UWB Communication Systems: Conventional and 60 GHz by
Cover of the book Three-Dimensional Imaging, Visualization, and Display by
Cover of the book Social Foundations of Human Space Exploration by
Cover of the book Functional Equations in Mathematical Analysis by
Cover of the book Renal Cell Carcinoma by
Cover of the book Enzymes in Anesthesiology by
Cover of the book Space Debris and Other Threats from Outer Space by
Cover of the book Fire Hazards of Exterior Wall Assemblies Containing Combustible Components by
Cover of the book Ecologist-Developed Spatially-Explicit Dynamic Landscape Models by
Cover of the book Psychological Co-morbidities of Physical Illness by
Cover of the book Watershed Management by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy