Transglutaminases

Multiple Functional Modifiers and Targets for New Drug Discovery

Nonfiction, Health & Well Being, Medical, Specialties, Pharmacy, Science & Nature, Science, Biological Sciences, Biochemistry, Technology
Cover of the book Transglutaminases by , Springer Japan
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9784431558255
Publisher: Springer Japan Publication: February 4, 2016
Imprint: Springer Language: English
Author:
ISBN: 9784431558255
Publisher: Springer Japan
Publication: February 4, 2016
Imprint: Springer
Language: English

This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of proteins, and interacting with a large number of proteins inside and outside of cells. Although several of their essential physiological roles have been revealed, many unknown and so far not fully understood functions have remained. In humans, there are eight active isozymes having distinct tissue and subcellular distribution patterns with different substrates and physiological roles. Accordingly, aberrant regulation of the enzyme reactions or expression may lead to or has been implicated in various pathologies including neurodegeneration, fibrosis, cancer, inflammation, celiac disease, and hemostasis disorders.To provide those who are new to the field with basic knowledge and recent information on transglutaminase structures and reactions, the mechanism by which transglutaminases modify substrate proteins and their contributions to multiple biological phenomena as well as disease phenotypes, the publication of the present transglutaminase book was planned, to consist of review articles by 17 expert investigators working in this exciting area of research. The book contains detailed information related to several transglutaminases from aspects in chemical and cellular biology, medical sciences, and biotechnology that will also supply starting points for drug discovery. Although many prominent findings have been published in recent years, this type of comprehensive review book has been missing in the scientific literature. This volume will be useful for investigators who either currently work on or will start addressing transglutaminase-related research, and beyond that, for a broad audience in the scientific community.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of proteins, and interacting with a large number of proteins inside and outside of cells. Although several of their essential physiological roles have been revealed, many unknown and so far not fully understood functions have remained. In humans, there are eight active isozymes having distinct tissue and subcellular distribution patterns with different substrates and physiological roles. Accordingly, aberrant regulation of the enzyme reactions or expression may lead to or has been implicated in various pathologies including neurodegeneration, fibrosis, cancer, inflammation, celiac disease, and hemostasis disorders.To provide those who are new to the field with basic knowledge and recent information on transglutaminase structures and reactions, the mechanism by which transglutaminases modify substrate proteins and their contributions to multiple biological phenomena as well as disease phenotypes, the publication of the present transglutaminase book was planned, to consist of review articles by 17 expert investigators working in this exciting area of research. The book contains detailed information related to several transglutaminases from aspects in chemical and cellular biology, medical sciences, and biotechnology that will also supply starting points for drug discovery. Although many prominent findings have been published in recent years, this type of comprehensive review book has been missing in the scientific literature. This volume will be useful for investigators who either currently work on or will start addressing transglutaminase-related research, and beyond that, for a broad audience in the scientific community.

More books from Springer Japan

Cover of the book Japanese Firms During the Lost Two Decades by
Cover of the book Development of Novel Anti-HIV Pyrimidobenzothiazine Derivatives by
Cover of the book Progress of Nuclear Safety for Symbiosis and Sustainability by
Cover of the book Magnetoelectric Response in Low-Dimensional Frustrated Spin Systems by
Cover of the book Role of Blood Flow in Atherogenesis by
Cover of the book Heat Shock Factor by
Cover of the book Sustainable Growth and Development in a Regional Economy by
Cover of the book Pathogenesis and Treatment in IgA Nephropathy by
Cover of the book A Bayesian Analysis of QCD Sum Rules by
Cover of the book Treatment of Thyroid Tumor by
Cover of the book Japan’s Industrious Revolution by
Cover of the book Cholesteatoma and Anterior Tympanotomy by
Cover of the book Spectroscopic Study on Charge-Spin-Orbital Coupled Phenomena in Mott-Transition Oxides by
Cover of the book Advances in Mathematical Economics Volume 18 by
Cover of the book Defects and Impurities in Silicon Materials by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy