Total Synthesis of Natural Products with Antimicrobial Activity

Nonfiction, Science & Nature, Science, Chemistry, Clinical, Health & Well Being, Medical, Medical Science, Biochemistry
Cover of the book Total Synthesis of Natural Products with Antimicrobial Activity by Andrew Giltrap, Springer Singapore
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Andrew Giltrap ISBN: 9789811088063
Publisher: Springer Singapore Publication: May 2, 2018
Imprint: Springer Language: English
Author: Andrew Giltrap
ISBN: 9789811088063
Publisher: Springer Singapore
Publication: May 2, 2018
Imprint: Springer
Language: English

This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) – teixobactin and the skyllamycins – with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) – teixobactin and the skyllamycins – with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.

More books from Springer Singapore

Cover of the book Universal Fuzzy Controllers for Non-affine Nonlinear Systems by Andrew Giltrap
Cover of the book Wireless Positioning: Principles and Practice by Andrew Giltrap
Cover of the book A Tutorial Introduction to VHDL Programming by Andrew Giltrap
Cover of the book Soft Computing: Theories and Applications by Andrew Giltrap
Cover of the book Advanced Multimedia and Ubiquitous Engineering by Andrew Giltrap
Cover of the book Role of Rhizospheric Microbes in Soil by Andrew Giltrap
Cover of the book Academic Governance in the Contemporary University by Andrew Giltrap
Cover of the book VLSI Design and Test by Andrew Giltrap
Cover of the book Geometry of Cauchy-Riemann Submanifolds by Andrew Giltrap
Cover of the book The Humanities in Contemporary Chinese Contexts by Andrew Giltrap
Cover of the book China's National Balance Sheet (2015): Leverage Adjustment and Risk Management by Andrew Giltrap
Cover of the book Software Engineering by Andrew Giltrap
Cover of the book Research into Design for a Connected World by Andrew Giltrap
Cover of the book FMEA Using Uncertainty Theories and MCDM Methods by Andrew Giltrap
Cover of the book Wave Propagation and Diffraction by Andrew Giltrap
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy