The UNC-53-mediated Interactome

Analysis of its Role in the Generation of the C. elegans Connectome

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Neuroscience, Science & Nature, Science, Biological Sciences, Zoology
Cover of the book The UNC-53-mediated Interactome by Amita Pandey, Girdhar K. Pandey, Springer International Publishing
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Author: Amita Pandey, Girdhar K. Pandey ISBN: 9783319078274
Publisher: Springer International Publishing Publication: July 5, 2014
Imprint: Springer Language: English
Author: Amita Pandey, Girdhar K. Pandey
ISBN: 9783319078274
Publisher: Springer International Publishing
Publication: July 5, 2014
Imprint: Springer
Language: English

This book gives an overview of various interactomes involved in dorsal ventral (DV) and anterior posterior (AP) guidance, their mechanisms of action, subcellular localizations, and functional roles. It will provide readers a better understanding of the development of the nervous system, which in turn will help to find cures to various neural and other disorders.​

In nematodes there are two types of guidance systems, including DV and AP guidance. The signaling process that guides the growth cones along the DV axis has remained intact in both vertebrates and invertebrates. The adaptor protein UNC-53 appears to play a part in migration along the AP axis in both worms and their human homologs. “Neuron Navigators” (NAV) are also involved in nervous system development 

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This book gives an overview of various interactomes involved in dorsal ventral (DV) and anterior posterior (AP) guidance, their mechanisms of action, subcellular localizations, and functional roles. It will provide readers a better understanding of the development of the nervous system, which in turn will help to find cures to various neural and other disorders.​

In nematodes there are two types of guidance systems, including DV and AP guidance. The signaling process that guides the growth cones along the DV axis has remained intact in both vertebrates and invertebrates. The adaptor protein UNC-53 appears to play a part in migration along the AP axis in both worms and their human homologs. “Neuron Navigators” (NAV) are also involved in nervous system development 

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