Target Validation in Drug Discovery

Nonfiction, Science & Nature, Science, Biological Sciences, Biotechnology, Health & Well Being, Medical, Medical Science, Pharmacology
Cover of the book Target Validation in Drug Discovery by , Elsevier Science
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Author: ISBN: 9780080465975
Publisher: Elsevier Science Publication: April 28, 2011
Imprint: Academic Press Language: English
Author:
ISBN: 9780080465975
Publisher: Elsevier Science
Publication: April 28, 2011
Imprint: Academic Press
Language: English

This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.

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This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.

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