Systems Analysis of Human Multigene Disorders

Nonfiction, Health & Well Being, Medical, Medical Science, Genetics, Science & Nature, Science, Biological Sciences
Cover of the book Systems Analysis of Human Multigene Disorders by , Springer New York
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Author: ISBN: 9781461487784
Publisher: Springer New York Publication: November 29, 2013
Imprint: Springer Language: English
Author:
ISBN: 9781461487784
Publisher: Springer New York
Publication: November 29, 2013
Imprint: Springer
Language: English

Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance.

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Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance.

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