Stress-Induced Mutagenesis

Nonfiction, Health & Well Being, Medical, Medical Science, Genetics, Science & Nature, Science, Biological Sciences, Biochemistry
Cover of the book Stress-Induced Mutagenesis by , Springer New York
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781461462804
Publisher: Springer New York Publication: March 12, 2013
Imprint: Springer Language: English
Author:
ISBN: 9781461462804
Publisher: Springer New York
Publication: March 12, 2013
Imprint: Springer
Language: English

The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes.

This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes.

This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.

More books from Springer New York

Cover of the book Metal-on-Metal Bearings by
Cover of the book Atomic Scale Characterization and First-Principles Studies of Si₃N₄ Interfaces by
Cover of the book Lectures on Polytopes by
Cover of the book Residues of Pesticides and Other Contaminants in the Total Environment by
Cover of the book Applied Evolutionary Anthropology by
Cover of the book Sustaining Entrepreneurship and Economic Growth by
Cover of the book Clinical Prediction Models by
Cover of the book Waves and Compressible Flow by
Cover of the book The ASCRS Manual of Colon and Rectal Surgery by
Cover of the book Radiation Therapy for Skin Cancer by
Cover of the book The Family in Medical Practice by
Cover of the book From Kinetic Models to Hydrodynamics by
Cover of the book Advances in Dynamic Network Modeling in Complex Transportation Systems by
Cover of the book Cellular and Molecular Regulation of Testicular Cells by
Cover of the book Contact Lenses in Ophthalmic Practice by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy