Spheroids in Cancer Research

Methods and Perspectives

Nonfiction, Health & Well Being, Medical, Medical Science, Biochemistry, Specialties, Oncology
Cover of the book Spheroids in Cancer Research by , Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783642823404
Publisher: Springer Berlin Heidelberg Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9783642823404
Publisher: Springer Berlin Heidelberg
Publication: December 6, 2012
Imprint: Springer
Language: English

Malignant growth of cells is often characterized by disorganization of tissue structure, abnormal blood vessel development, and insuffi­ cient vascular supply. As a consequence, the cancer cells grow in a three-dimensional pattern in atypical microenvironments which include physical, chemical, and nutritional stresses. Necrosis often develops some distance away from the blood vessels. In association with an inherent instability in malignant cell populations, and also because of the changing micromilieu, significant cellular heteroge­ neity emerges with regard to various phenotypic characteristics. Both biological behavior and responses to therapeutic agents can be affected. A variety of in vitro and in vivo experimental models exist for research on properties of cancer cells during growth. The multicell spheroid model was developed as a system of intermediate complexity in which three dimensional growth of cells enhances cell-cell interactions and creates micro environments that simulate the conditions in intervascular microregions of tumors or microme­ tastatic foci. Spheroids may change their cellular characteristics with changing environments during growth. These can be studied under controlled conditions in vitro. Interest in details of experimental methods for this model system stimulated the organization of the First International Conference in Rochester, NY in 1980, the Proceedings of which were summarized in Cancer Research in 1981. Since then there has been a rapid increase in the use of this model system, and increased research on the significance of cell-cell and cell-microenvironment interactions in biology in general.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Malignant growth of cells is often characterized by disorganization of tissue structure, abnormal blood vessel development, and insuffi­ cient vascular supply. As a consequence, the cancer cells grow in a three-dimensional pattern in atypical microenvironments which include physical, chemical, and nutritional stresses. Necrosis often develops some distance away from the blood vessels. In association with an inherent instability in malignant cell populations, and also because of the changing micromilieu, significant cellular heteroge­ neity emerges with regard to various phenotypic characteristics. Both biological behavior and responses to therapeutic agents can be affected. A variety of in vitro and in vivo experimental models exist for research on properties of cancer cells during growth. The multicell spheroid model was developed as a system of intermediate complexity in which three dimensional growth of cells enhances cell-cell interactions and creates micro environments that simulate the conditions in intervascular microregions of tumors or microme­ tastatic foci. Spheroids may change their cellular characteristics with changing environments during growth. These can be studied under controlled conditions in vitro. Interest in details of experimental methods for this model system stimulated the organization of the First International Conference in Rochester, NY in 1980, the Proceedings of which were summarized in Cancer Research in 1981. Since then there has been a rapid increase in the use of this model system, and increased research on the significance of cell-cell and cell-microenvironment interactions in biology in general.

More books from Springer Berlin Heidelberg

Cover of the book Flux Pinning in Superconductors by
Cover of the book Microsimulation Modelling of the Corporate Firm by
Cover of the book Therapie der Krankheiten im Kindes- und Jugendalter by
Cover of the book Polymere: Synthese, Eigenschaften und Anwendungen by
Cover of the book Silicone Oil in the Treatment of Complicated Retinal Detachments by
Cover of the book Long Non-Coding RNAs by
Cover of the book Cell Culture in Pharmaceutical Research by
Cover of the book Inborn Metabolic Diseases by
Cover of the book Grundkurs Theoretische Physik 7 by
Cover of the book Technologiemanagement by
Cover of the book Erfolgreiche agile Projekte by
Cover of the book The Complement System by
Cover of the book Profiting from Innovation in China by
Cover of the book Electromagnetics and Network Theory and their Microwave Technology Applications by
Cover of the book Datenqualität in Stichprobenerhebungen by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy