Sirtuins in Health and Disease

Nonfiction, Science & Nature, Science, Other Sciences, Molecular Biology, Biological Sciences, Biochemistry
Cover of the book Sirtuins in Health and Disease by Weiping Zheng, Elsevier Science
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Author: Weiping Zheng ISBN: 9780128122624
Publisher: Elsevier Science Publication: February 3, 2018
Imprint: Academic Press Language: English
Author: Weiping Zheng
ISBN: 9780128122624
Publisher: Elsevier Science
Publication: February 3, 2018
Imprint: Academic Press
Language: English

Sirtuins in Health and Disease, Volume 154 presents the reactions catalyzed by sirtuins in terms of their unique coenzyme NAD+-dependent catalytic mechanisms, the ways to elucidate these mechanisms, and the design of the inhibitory compounds against the sirtuin-catalyzed reactions as potential therapeutic agents for human diseases. Sections cover the concepts and chemical tools in sirtuin research, SIRT4 and SIRT7, the regulatory effects of NAD metabolic pathways on sirtuin activity, sirtuins as modifiers of Huntington’s Disease (HD) pathology, parasite sirtuins as targets for novel chemotherapeutic agents, targeting sirtuins – substrate specificity and inhibitor design, and chemical probes in sirtuin research.

This book focuses on the outstanding issues in the sirtuin field and implications for future sirtuin research.

  • Presents an excellent subject, excellent structural organization, and authoritative contributions from world-renowned scholars in the sirtuin field
  • Provides the latest updates on sirtuins in health and disease
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Sirtuins in Health and Disease, Volume 154 presents the reactions catalyzed by sirtuins in terms of their unique coenzyme NAD+-dependent catalytic mechanisms, the ways to elucidate these mechanisms, and the design of the inhibitory compounds against the sirtuin-catalyzed reactions as potential therapeutic agents for human diseases. Sections cover the concepts and chemical tools in sirtuin research, SIRT4 and SIRT7, the regulatory effects of NAD metabolic pathways on sirtuin activity, sirtuins as modifiers of Huntington’s Disease (HD) pathology, parasite sirtuins as targets for novel chemotherapeutic agents, targeting sirtuins – substrate specificity and inhibitor design, and chemical probes in sirtuin research.

This book focuses on the outstanding issues in the sirtuin field and implications for future sirtuin research.

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