Role of the Transcriptome in Breast Cancer Prevention

Nonfiction, Health & Well Being, Medical, Specialties, Oncology, Medical Science, Pharmacology
Cover of the book Role of the Transcriptome in Breast Cancer Prevention by Irma H. Russo, Jose Russo, Springer US
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Irma H. Russo, Jose Russo ISBN: 9781461448846
Publisher: Springer US Publication: November 7, 2012
Imprint: Springer Language: English
Author: Irma H. Russo, Jose Russo
ISBN: 9781461448846
Publisher: Springer US
Publication: November 7, 2012
Imprint: Springer
Language: English

This book will provide the latest advances in molecular and cellular biology for establishing the foundation of a complete understanding of the mechanisms of breast differentiation leading to cancer prevention. The authors are based on the epidemiological evidence indicating that early first full term pregnancy is a protective factor in human against breast cancer and they have used this paradigm and developed experimental systems in both in vivo and in vitro that have demonstrated mechanistically how the differentiation at the organ and cellular level takes place. This knowledge has provided the blueprint for developing better understanding of the basis of cancer prevention. The transcriptoma analysis of the breast of pre and post-menopausal women has established a genomic signature imprinted in the breast that differs according to the reproductive history of the woman showing that early first full term pregnancy reprogram the organ. This reprogramming takes place at the chromatin level by changing the transcriptional process. The modification of the transcriptional control is due to the expression of non coding RNA sequences and posttranscriptional control driven by the splicesome. The plasticity of the genome of the human breast make possible this reprogramming that is not only induced by the physiological process of pregnancy but by the use of hormones that mimic pregnancy without pregnancy. The author have established the basis of clinical trials for prevention and the discovery that short 15aa peptides of the chorionic gonadotropin hormone can be used in human breast cancer prevention based on preclinical and clinical data.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This book will provide the latest advances in molecular and cellular biology for establishing the foundation of a complete understanding of the mechanisms of breast differentiation leading to cancer prevention. The authors are based on the epidemiological evidence indicating that early first full term pregnancy is a protective factor in human against breast cancer and they have used this paradigm and developed experimental systems in both in vivo and in vitro that have demonstrated mechanistically how the differentiation at the organ and cellular level takes place. This knowledge has provided the blueprint for developing better understanding of the basis of cancer prevention. The transcriptoma analysis of the breast of pre and post-menopausal women has established a genomic signature imprinted in the breast that differs according to the reproductive history of the woman showing that early first full term pregnancy reprogram the organ. This reprogramming takes place at the chromatin level by changing the transcriptional process. The modification of the transcriptional control is due to the expression of non coding RNA sequences and posttranscriptional control driven by the splicesome. The plasticity of the genome of the human breast make possible this reprogramming that is not only induced by the physiological process of pregnancy but by the use of hormones that mimic pregnancy without pregnancy. The author have established the basis of clinical trials for prevention and the discovery that short 15aa peptides of the chorionic gonadotropin hormone can be used in human breast cancer prevention based on preclinical and clinical data.

More books from Springer US

Cover of the book The Biology of Alcoholism by Irma H. Russo, Jose Russo
Cover of the book Andean Archaeology I by Irma H. Russo, Jose Russo
Cover of the book Agricultural Markets Beyond Liberalization by Irma H. Russo, Jose Russo
Cover of the book Challenging Mathematics In and Beyond the Classroom by Irma H. Russo, Jose Russo
Cover of the book Electrostatic and Stereoelectronic Effects in Carbohydrate Chemistry by Irma H. Russo, Jose Russo
Cover of the book Alexander Romanovich Luria by Irma H. Russo, Jose Russo
Cover of the book Principles of Food Processing by Irma H. Russo, Jose Russo
Cover of the book Design of Low-Voltage Bipolar Operational Amplifiers by Irma H. Russo, Jose Russo
Cover of the book Manual of Clinical Dialysis by Irma H. Russo, Jose Russo
Cover of the book Oesophageal Atresia by Irma H. Russo, Jose Russo
Cover of the book Handbook of Response to Intervention by Irma H. Russo, Jose Russo
Cover of the book Traditional Family Values and Substance Abuse by Irma H. Russo, Jose Russo
Cover of the book Advances in Modeling Agricultural Systems by Irma H. Russo, Jose Russo
Cover of the book Biorelated Polymers by Irma H. Russo, Jose Russo
Cover of the book Women’s Progress by Irma H. Russo, Jose Russo
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy