Role of Capsaicin in Oxidative Stress and Cancer

Nonfiction, Health & Well Being, Medical, Specialties, Oncology, Science & Nature, Science
Cover of the book Role of Capsaicin in Oxidative Stress and Cancer by , Springer Netherlands
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Author: ISBN: 9789400763173
Publisher: Springer Netherlands Publication: April 23, 2013
Imprint: Springer Language: English
Author:
ISBN: 9789400763173
Publisher: Springer Netherlands
Publication: April 23, 2013
Imprint: Springer
Language: English

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.

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This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.

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