Resistance to Molecular Therapies for Hepatocellular Carcinoma

Nonfiction, Health & Well Being, Medical, Specialties, Oncology
Cover of the book Resistance to Molecular Therapies for Hepatocellular Carcinoma by , Springer International Publishing
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Author: ISBN: 9783319561974
Publisher: Springer International Publishing Publication: July 14, 2017
Imprint: Springer Language: English
Author:
ISBN: 9783319561974
Publisher: Springer International Publishing
Publication: July 14, 2017
Imprint: Springer
Language: English

This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment; determines the role of the cancer stem cell phenotype in resistance; reviews the experimental models to study resistance; and addresses new approaches to overcome resistance to sorafenib, using successful examples from other malignancies. 

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This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment; determines the role of the cancer stem cell phenotype in resistance; reviews the experimental models to study resistance; and addresses new approaches to overcome resistance to sorafenib, using successful examples from other malignancies. 

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