Resistance to Aromatase Inhibitors in Breast Cancer

Nonfiction, Health & Well Being, Medical, Medical Science, Pharmacology, Specialties, Oncology
Cover of the book Resistance to Aromatase Inhibitors in Breast Cancer by , Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783319179728
Publisher: Springer International Publishing Publication: April 25, 2015
Imprint: Springer Language: English
Author:
ISBN: 9783319179728
Publisher: Springer International Publishing
Publication: April 25, 2015
Imprint: Springer
Language: English

Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental , and clinical data specifically focused on AI resistance in breast cancer. The volume will include three sections. The first section covers general knowledge about aromatase inhibitors, including regulation of aromatase genes, and structure and function of aromatase protein. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance. Breast cancer is the most common female cancer and AIs significantly improve treatments outcomes compatibly to previously used endocrine treatments. However 10-15% of post-operative patients develop a relapse during adjuvant treatment with AIs; about 25-50% of the patients do not respond to AIs in neo-adjuvant or metastatic setting, and the majority of metastatic patients who initially respond develop resistance within 3 years. There is an important need to understand these mechanisms of resistance in order to develop methods of preventing or overcoming the resistance to AIs, which will ensure a more successful outcome in treating breast cancer.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental , and clinical data specifically focused on AI resistance in breast cancer. The volume will include three sections. The first section covers general knowledge about aromatase inhibitors, including regulation of aromatase genes, and structure and function of aromatase protein. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance. Breast cancer is the most common female cancer and AIs significantly improve treatments outcomes compatibly to previously used endocrine treatments. However 10-15% of post-operative patients develop a relapse during adjuvant treatment with AIs; about 25-50% of the patients do not respond to AIs in neo-adjuvant or metastatic setting, and the majority of metastatic patients who initially respond develop resistance within 3 years. There is an important need to understand these mechanisms of resistance in order to develop methods of preventing or overcoming the resistance to AIs, which will ensure a more successful outcome in treating breast cancer.

More books from Springer International Publishing

Cover of the book Science, Museums and Collecting the Indigenous Dead in Colonial Australia by
Cover of the book Deep Time Analysis by
Cover of the book Solar Cells Based on Colloidal Nanocrystals by
Cover of the book Landscape Planning and Rural Development by
Cover of the book Large-Scale Studies in Mathematics Education by
Cover of the book Ensuring Quality in Professional Education Volume II by
Cover of the book Coordination, Organizations, Institutions, and Norms in Agent Systems XI by
Cover of the book The Paris Agreement by
Cover of the book The Ixodid Ticks (Acari: Ixodidae) of Southern Africa by
Cover of the book Embedded Flash Memory for Embedded Systems: Technology, Design for Sub-systems, and Innovations by
Cover of the book Computer Science – Theory and Applications by
Cover of the book Mechanical Properties of Aging Soft Tissues by
Cover of the book Helmut Schmidt by
Cover of the book TP-Model Transformation-Based-Control Design Frameworks by
Cover of the book Business Process Management Workshops by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy