Purinergic Signalling and the Nervous System

Nonfiction, Health & Well Being, Medical, Medical Science, Physiology
Cover of the book Purinergic Signalling and the Nervous System by Geoffrey Burnstock, Verkhratsky Alexei, Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Geoffrey Burnstock, Verkhratsky Alexei ISBN: 9783642288630
Publisher: Springer Berlin Heidelberg Publication: June 5, 2012
Imprint: Springer Language: English
Author: Geoffrey Burnstock, Verkhratsky Alexei
ISBN: 9783642288630
Publisher: Springer Berlin Heidelberg
Publication: June 5, 2012
Imprint: Springer
Language: English

In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents.

In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents.

In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.

More books from Springer Berlin Heidelberg

Cover of the book Optimization of Solid Waste Conversion Process and Risk Control of Groundwater Pollution by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Incidental Carcinoma of the Prostate by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Väter und ihre Söhne by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Alternate Methods in the Treatment of Benign Prostatic Hyperplasia by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Geo-Informatics in Resource Management and Sustainable Ecosystem by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Lasers in the Musculoskeletal System by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book The Subchondral Bone Plate by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Resilienzförderung im Jugendalter by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Kompendium Orthopädische Bildgebung by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Cardiac Pacing by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Gynecological Tumors by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Biocompatible Graphene for Bioanalytical Applications by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Minimizing Incisions and Maximizing Outcomes in Cataract Surgery by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Update in Cosmetic Dermatology by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Die Zukunft der Psychotherapie by Geoffrey Burnstock, Verkhratsky Alexei
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy