Polymers and Nanomaterials for Gene Therapy

Nonfiction, Science & Nature, Technology, Textiles & Polymers, Science, Biological Sciences, Genetics
Cover of the book Polymers and Nanomaterials for Gene Therapy by , Elsevier Science
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9780081005217
Publisher: Elsevier Science Publication: January 9, 2016
Imprint: Woodhead Publishing Language: English
Author:
ISBN: 9780081005217
Publisher: Elsevier Science
Publication: January 9, 2016
Imprint: Woodhead Publishing
Language: English

Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy.

The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy.

This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy.

  • Explores current challenges in the research of genetic diseases
  • Discusses polymers for gene therapy and their function in designing advanced materials
  • Provides examples of organic and inorganic nanomaterials for gene therapy
  • Includes labeling, targeting, and assays
  • Looks at characterization, physico-(bio)chemical properties, and applications
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy.

The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy.

This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy.

More books from Elsevier Science

Cover of the book Engineering Tribology by
Cover of the book Ergonomic Solutions for the Process Industries by
Cover of the book Neurochemistry of the Retina by
Cover of the book Pump Users Handbook by
Cover of the book The Molecular Nutrition of Amino Acids and Proteins by
Cover of the book Nanostructures for Novel Therapy by
Cover of the book The Ancient Human Occupation of Britain by
Cover of the book Signals and Systems using MATLAB by
Cover of the book Food Protection and Security by
Cover of the book Comprehensive Chemometrics by
Cover of the book Proteomic and Metabolomic Approaches to Biomarker Discovery by
Cover of the book Biofuels by
Cover of the book Coal Power Plant Materials and Life Assessment by
Cover of the book Activated Carbon by
Cover of the book Solid State Physics by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy