Polyglutamine Disorders

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Neuroscience, Neurology, Science & Nature, Science
Cover of the book Polyglutamine Disorders by , Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783319717791
Publisher: Springer International Publishing Publication: February 9, 2018
Imprint: Springer Language: English
Author:
ISBN: 9783319717791
Publisher: Springer International Publishing
Publication: February 9, 2018
Imprint: Springer
Language: English

This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies’ development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. 

Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington’s disease (HD); spinal–bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17).

The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies’ development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. 

Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington’s disease (HD); spinal–bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17).

The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.

More books from Springer International Publishing

Cover of the book Pole Solutions for Flame Front Propagation by
Cover of the book Ethical Decision Making: Introduction to Cases and Concepts in Ethics by
Cover of the book Progress in Nanophotonics 5 by
Cover of the book Economics of Grids, Clouds, Systems, and Services by
Cover of the book Establishing a Hematopoietic Stem Cell Transplantation Unit by
Cover of the book Sustainable Air Pollution Management by
Cover of the book Handbook of Ripple Effects in the Supply Chain by
Cover of the book Neuropsychological Assessments of Dementia in Down Syndrome and Intellectual Disabilities by
Cover of the book Innovation in Medicine and Healthcare 2016 by
Cover of the book Nanocomposites, Nanostructures, and Their Applications by
Cover of the book Respectable Deviance and Purchasing Medicine Online by
Cover of the book One Hundred Prisoners and a Light Bulb by
Cover of the book Historical Perspectives on the State of Health and Health Systems in Africa, Volume I by
Cover of the book EU Crisis and the Role of the Periphery by
Cover of the book Transrational Resonances by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy