Pointers to Cancer Prognosis

Nonfiction, Health & Well Being, Medical, Specialties, Oncology
Cover of the book Pointers to Cancer Prognosis by , Springer Netherlands
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9789400932913
Publisher: Springer Netherlands Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9789400932913
Publisher: Springer Netherlands
Publication: December 6, 2012
Imprint: Springer
Language: English

The last 30 years have seen little improvement in the age-adjusted mortality rates for most common types of cancer, and until we develop more effective and less damaging treatment modalities for these tumours, selection of each patient's treatment must depend on prognostic pointers. These lead to a calculated trade­ off between our estimate of likely benefit to the patient, as against cost in terms of quality of life. But changes have occurred recently in our understanding of the traditional prognostic pointers used for selecting such individualised treatment. First, it is increasingly recognised that the stage at which a tumour presents is more related to the chromo logical age of the tumour (how far it has progressed before diagnosis) than to its biological characteristics. While advanced chronological age of the tumour may predict a greater likelihood of early death, only biological criteria can predict the tumour growth rate, the likelihood of prolonged survival, the likely course of the disease after the first recurrence or the likehood of response to systemic therapy. Second, there is increasing use of failure analysis in relating the clinical and biological characteristics of tumours to their response to standard treatments. In the past, the relationship was interpreted mainly in terms of survival rate, but the site and timing of first recurrence and the pattern and timing of subsequent spread provide a better assessment of the control possible from local or systemic therapy.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The last 30 years have seen little improvement in the age-adjusted mortality rates for most common types of cancer, and until we develop more effective and less damaging treatment modalities for these tumours, selection of each patient's treatment must depend on prognostic pointers. These lead to a calculated trade­ off between our estimate of likely benefit to the patient, as against cost in terms of quality of life. But changes have occurred recently in our understanding of the traditional prognostic pointers used for selecting such individualised treatment. First, it is increasingly recognised that the stage at which a tumour presents is more related to the chromo logical age of the tumour (how far it has progressed before diagnosis) than to its biological characteristics. While advanced chronological age of the tumour may predict a greater likelihood of early death, only biological criteria can predict the tumour growth rate, the likelihood of prolonged survival, the likely course of the disease after the first recurrence or the likehood of response to systemic therapy. Second, there is increasing use of failure analysis in relating the clinical and biological characteristics of tumours to their response to standard treatments. In the past, the relationship was interpreted mainly in terms of survival rate, but the site and timing of first recurrence and the pattern and timing of subsequent spread provide a better assessment of the control possible from local or systemic therapy.

More books from Springer Netherlands

Cover of the book Statistical Physics of Nanoparticles in the Gas Phase by
Cover of the book Neuro-Robotics by
Cover of the book Voluntary Termination of Pregnancy by
Cover of the book Electrifying Atmospheres: Charging, Ionisation and Lightning in the Solar System and Beyond by
Cover of the book The Changing Profile of the Natural Law by
Cover of the book The Spectrum of Social Time by
Cover of the book Comparative Information Technology by
Cover of the book The Myelodysplastic Syndromes by
Cover of the book Illustrated Encyclopedia of Dermatology by
Cover of the book Mao Tse-Tung’s Theory of Dialectic by
Cover of the book Handbook of Bioethics: by
Cover of the book Lifelong Education by
Cover of the book Protein Function Prediction for Omics Era by
Cover of the book Climate Change and Sustainable Urban Development in Africa and Asia by
Cover of the book First International Congress on Cataract Surgery Florence, 1978 by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy