Phasing in Crystallography

A Modern Perspective

Nonfiction, Science & Nature, Science, Chemistry, Crystallography, Technology
Cover of the book Phasing in Crystallography by Carmelo Giacovazzo, OUP Oxford
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Carmelo Giacovazzo ISBN: 9780191510625
Publisher: OUP Oxford Publication: December 12, 2013
Imprint: OUP Oxford Language: English
Author: Carmelo Giacovazzo
ISBN: 9780191510625
Publisher: OUP Oxford
Publication: December 12, 2013
Imprint: OUP Oxford
Language: English

Modern crystallographic methods originate from the synergy of two main research streams, the small-molecule and the macro-molecular streams. The first stream was able to definitively solve the phase problem for molecules up to 200 atoms in the asymmetric unit. The achievements obtained by the macromolecular stream are also impressive. A huge number of protein structures have been deposited in the Protein Data Bank. The solution of them is no longer reserved to an elite group of scientists, but may be attained in a large number of laboratories around the world, even by young scientists. New probabilistic approaches have been tailored to deal with larger structures, errors in the experimental data, and modest data resolution. Traditional phasing techniques like ab initio, molecular replacement, isomorphous replacement, and anomalous dispersion techniques have been revisited. The new approaches have been implemented in robust phasing programs, which have been organized in automatic pipelines usable even by non-experts. Protein structures, which 50 years ago could take months or even years to solve, can now be solved in a matter of hours, partly also due to technological advances in computer science. This book describes all modern crystallographic phasing methods, and introduces a new rational classification of them. A didactic approach is used, with the techniques described simply and logically in the main text, and further mathematical details confined to the Appendices for motivated readers. Numerous figures and applicative details illustrate the text.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Modern crystallographic methods originate from the synergy of two main research streams, the small-molecule and the macro-molecular streams. The first stream was able to definitively solve the phase problem for molecules up to 200 atoms in the asymmetric unit. The achievements obtained by the macromolecular stream are also impressive. A huge number of protein structures have been deposited in the Protein Data Bank. The solution of them is no longer reserved to an elite group of scientists, but may be attained in a large number of laboratories around the world, even by young scientists. New probabilistic approaches have been tailored to deal with larger structures, errors in the experimental data, and modest data resolution. Traditional phasing techniques like ab initio, molecular replacement, isomorphous replacement, and anomalous dispersion techniques have been revisited. The new approaches have been implemented in robust phasing programs, which have been organized in automatic pipelines usable even by non-experts. Protein structures, which 50 years ago could take months or even years to solve, can now be solved in a matter of hours, partly also due to technological advances in computer science. This book describes all modern crystallographic phasing methods, and introduces a new rational classification of them. A didactic approach is used, with the techniques described simply and logically in the main text, and further mathematical details confined to the Appendices for motivated readers. Numerous figures and applicative details illustrate the text.

More books from OUP Oxford

Cover of the book The Ordnance Survey and Modern Irish Literature by Carmelo Giacovazzo
Cover of the book Secure Lives by Carmelo Giacovazzo
Cover of the book Religious Freedom in the Liberal State by Carmelo Giacovazzo
Cover of the book Adolescence: A Very Short Introduction by Carmelo Giacovazzo
Cover of the book Where Our Protection Lies by Carmelo Giacovazzo
Cover of the book The Memoirs of Sherlock Holmes by Carmelo Giacovazzo
Cover of the book Big Questions in Ecology and Evolution by Carmelo Giacovazzo
Cover of the book Atonement by Carmelo Giacovazzo
Cover of the book Nazis on the Run by Carmelo Giacovazzo
Cover of the book The Oxford Handbook of Corporate Law and Governance by Carmelo Giacovazzo
Cover of the book The Eustace Diamonds by Carmelo Giacovazzo
Cover of the book A Dictionary of Critical Theory by Carmelo Giacovazzo
Cover of the book International Climate Change Law by Carmelo Giacovazzo
Cover of the book Foxe's Book of Martyrs by Carmelo Giacovazzo
Cover of the book Saltpeter by Carmelo Giacovazzo
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy