Numerical Methods for the Life Scientist

Binding and Enzyme Kinetics Calculated with GNU Octave and MATLAB

Nonfiction, Science & Nature, Science, Biological Sciences, Physiology, Computers, Advanced Computing, Computer Science
Cover of the book Numerical Methods for the Life Scientist by Heino Prinz, Springer Berlin Heidelberg
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Author: Heino Prinz ISBN: 9783642208201
Publisher: Springer Berlin Heidelberg Publication: August 6, 2011
Imprint: Springer Language: English
Author: Heino Prinz
ISBN: 9783642208201
Publisher: Springer Berlin Heidelberg
Publication: August 6, 2011
Imprint: Springer
Language: English

Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered.

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Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered.

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