Nuclear Receptors: From Structure to the Clinic

Nonfiction, Health & Well Being, Medical, Medical Science, Genetics, Specialties, Internal Medicine, Endocrinology & Metabolism
Cover of the book Nuclear Receptors: From Structure to the Clinic by , Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783319187297
Publisher: Springer International Publishing Publication: August 20, 2015
Imprint: Springer Language: English
Author:
ISBN: 9783319187297
Publisher: Springer International Publishing
Publication: August 20, 2015
Imprint: Springer
Language: English

Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity.

The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.    ​

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity.

The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.    ​

More books from Springer International Publishing

Cover of the book Electronic Properties of Graphene Heterostructures with Hexagonal Crystals by
Cover of the book Cloud Computing – CLOUD 2018 by
Cover of the book Nantgarw and Swansea Porcelains by
Cover of the book Operator Approximant Problems Arising from Quantum Theory by
Cover of the book Fair Trial and Judicial Independence by
Cover of the book The Last Natural Man by
Cover of the book Transport Phenomena in Newtonian Fluids - A Concise Primer by
Cover of the book A Starter on Support-Bargaining and Money-Bargaining in Twenty-Eight Digestible Bites by
Cover of the book Mathematical Control Theory II by
Cover of the book Personal Participation in Criminal Proceedings by
Cover of the book The Italian Water Industry by
Cover of the book Global Sport Leaders by
Cover of the book Proceedings of the 16th International Conference on Hybrid Intelligent Systems (HIS 2016) by
Cover of the book Models and Methods in Economics and Management Science by
Cover of the book The Impact of Pen and Touch Technology on Education by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy