Nuclear Pore Complexes in Genome Organization, Function and Maintenance

Nonfiction, Science & Nature, Science, Other Sciences, Molecular Biology, Health & Well Being, Medical, Medical Science, Genetics
Cover of the book Nuclear Pore Complexes in Genome Organization, Function and Maintenance by , Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783319716145
Publisher: Springer International Publishing Publication: February 2, 2018
Imprint: Springer Language: English
Author:
ISBN: 9783319716145
Publisher: Springer International Publishing
Publication: February 2, 2018
Imprint: Springer
Language: English

The three-dimensional organization of the DNA inside the eukaryotic cell nucleus has emerged a critical regulator of genome integrity and function. Increasing evidence indicates that nuclear pore complexes (NPCs), the large protein channels that connect the nucleus to the cytoplasm, play a critical role in the establishment and maintenance of chromatin organization and in the regulation of gene activity. These findings, which oppose the traditional view of NPCs as channels with only one: the facilitation of nucleocytoplasmic molecule exchange, have completely transformed our understanding of these structures. This book describes our current knowledge of the role of NPCs in genome organization and gene expression regulation. It starts by providing an overview of the different compartments and structures of the nucleus and how they contribute to organizing the genome, then moves to examine the direct roles of NPCs and their components in gene expression regulation in different organisms, and ends by describing the function of nuclear pores in the infection and genome integration of HIV, in DNA repair and telomere maintenance, and in the regulation of chromosome segregation and mitosis. This book provides an intellectual backdrop for anyone interested in understanding how the gatekeepers of the nucleus contribute to safeguarding the integrity and function of the eukaryotic genome. 

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The three-dimensional organization of the DNA inside the eukaryotic cell nucleus has emerged a critical regulator of genome integrity and function. Increasing evidence indicates that nuclear pore complexes (NPCs), the large protein channels that connect the nucleus to the cytoplasm, play a critical role in the establishment and maintenance of chromatin organization and in the regulation of gene activity. These findings, which oppose the traditional view of NPCs as channels with only one: the facilitation of nucleocytoplasmic molecule exchange, have completely transformed our understanding of these structures. This book describes our current knowledge of the role of NPCs in genome organization and gene expression regulation. It starts by providing an overview of the different compartments and structures of the nucleus and how they contribute to organizing the genome, then moves to examine the direct roles of NPCs and their components in gene expression regulation in different organisms, and ends by describing the function of nuclear pores in the infection and genome integration of HIV, in DNA repair and telomere maintenance, and in the regulation of chromosome segregation and mitosis. This book provides an intellectual backdrop for anyone interested in understanding how the gatekeepers of the nucleus contribute to safeguarding the integrity and function of the eukaryotic genome. 

More books from Springer International Publishing

Cover of the book Intelligent Techniques in Signal Processing for Multimedia Security by
Cover of the book The Scaling of Relaxation Processes by
Cover of the book The Power of Identity and Ideology in Language Learning by
Cover of the book Charles Olivier and the Rise of Meteor Science by
Cover of the book Integrated Community-Managed Development by
Cover of the book Requirements Engineering by
Cover of the book Advances in the Control of Markov Jump Linear Systems with No Mode Observation by
Cover of the book The Legal Technology Guidebook by
Cover of the book Computational Diffusion MRI by
Cover of the book Using R for Digital Soil Mapping by
Cover of the book Thermal Protection Modeling of Hypersonic Flying Apparatus by
Cover of the book The Role of Submarine Groundwater Discharge as Material Source to the Baltic Sea by
Cover of the book Leakage Resilient Password Systems by
Cover of the book Wage Inequality in Africa by
Cover of the book Adaptive Regression for Modeling Nonlinear Relationships by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy