Nuclear Export of Viral RNAs

Nonfiction, Health & Well Being, Medical, Medical Science, Microbiology, Science & Nature, Science, Biological Sciences
Cover of the book Nuclear Export of Viral RNAs by , Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783642565977
Publisher: Springer Berlin Heidelberg Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9783642565977
Publisher: Springer Berlin Heidelberg
Publication: December 6, 2012
Imprint: Springer
Language: English

In eukaryotic cells, the nuclear genome and its transcriptional apparatus is separated from the site of protein synthesis by the nuclear envelope. Thus, a constant flow of proteins and nucleic acids has to cross the nuclear envelope in both directions. This transport in and out of the nucleus is mediated by nuclear pore complexes (NPCs) and occurs in an energy and signal-dependent manner. Thus, nucleocytoplasmic translocation of macro­ molecules across the nuclear envelope appears to be a highly specific and regulated process. Viruses that replicate their genome in the cell nucleus are therefore forced to develop efficient ways to deal with the intracellulZlr host cell transport machinery. Historically, investigation of Polyomavirus replication allowed identification ofsequences that mediate nuclear import, which led subsequently to our detailed understanding of the cellular factors that are involved in nuclear import. Transport ofmacromolecules in the opposite direction, however, is less well understood. The investigation of retroviral gene expression in recent years pro­ vided the first insights into the cellular mechanisms that regulate nuclear export. In particular, the detailed dissection of the function of the human immunodeficiency virus type I (HIV-I) Rev trans-activator protein identified CRMI, as a hona fide nuclear export receptor. CRM I appears to be involved in the nucleocytoplasmic translocation of the vast majority of viral and cellular proteins that have subsequently been found to contain a Rev-type leucine-rich nuclear export signal (NES).

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

In eukaryotic cells, the nuclear genome and its transcriptional apparatus is separated from the site of protein synthesis by the nuclear envelope. Thus, a constant flow of proteins and nucleic acids has to cross the nuclear envelope in both directions. This transport in and out of the nucleus is mediated by nuclear pore complexes (NPCs) and occurs in an energy and signal-dependent manner. Thus, nucleocytoplasmic translocation of macro­ molecules across the nuclear envelope appears to be a highly specific and regulated process. Viruses that replicate their genome in the cell nucleus are therefore forced to develop efficient ways to deal with the intracellulZlr host cell transport machinery. Historically, investigation of Polyomavirus replication allowed identification ofsequences that mediate nuclear import, which led subsequently to our detailed understanding of the cellular factors that are involved in nuclear import. Transport ofmacromolecules in the opposite direction, however, is less well understood. The investigation of retroviral gene expression in recent years pro­ vided the first insights into the cellular mechanisms that regulate nuclear export. In particular, the detailed dissection of the function of the human immunodeficiency virus type I (HIV-I) Rev trans-activator protein identified CRMI, as a hona fide nuclear export receptor. CRM I appears to be involved in the nucleocytoplasmic translocation of the vast majority of viral and cellular proteins that have subsequently been found to contain a Rev-type leucine-rich nuclear export signal (NES).

More books from Springer Berlin Heidelberg

Cover of the book Stochastic Calculus with Infinitesimals by
Cover of the book Bismuth-Mediated Organic Reactions by
Cover of the book Innovation and International Corporate Growth by
Cover of the book Rechtsfragen der Obduktion und postmortalen Gewebespende by
Cover of the book Hair and Hair Diseases by
Cover of the book Algorithms in Bioinformatics by
Cover of the book The Neurons of the First Optic Ganglion of the Bee (Apis mellifera) by
Cover of the book Psycho-Logic by
Cover of the book Handbook of Polymer Nanocomposites. Processing, Performance and Application by
Cover of the book Climate Impacts on the Baltic Sea: From Science to Policy by
Cover of the book Lymphocytes, Macrophages, and Cancer by
Cover of the book Enterprise Information Systems by
Cover of the book A Concise Guide to Nuclear Medicine by
Cover of the book CSR und Fashion by
Cover of the book Sulphide Silver Pattern and Cytoarchitectonics of Parahippocampal Areas in the Rat by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy