Non-dopamine Lesions in Parkinson's Disease

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Neuroscience, Neurology
Cover of the book Non-dopamine Lesions in Parkinson's Disease by , Oxford University Press
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9780190208738
Publisher: Oxford University Press Publication: November 15, 2010
Imprint: Oxford University Press Language: English
Author:
ISBN: 9780190208738
Publisher: Oxford University Press
Publication: November 15, 2010
Imprint: Oxford University Press
Language: English

Parkinson's disease becomes apparent only after substantial loss (>60%) of the dopamine neurons in the substantia nigra. By this time there has already been widespread neural inclusion formation in the peripheral and central nervous system of patients with the disease, although this has only been recognized more recently. Degeneration in these widespread regions of the peripheral and central nervous system is now known to impact on disease symptoms, progression and treatment over time. This book aims to provide a comprehensive review of these non-dopamine lesions in Parkinson's disease by assessing our current knowledge of their presence and pathophysiology, how they relate to different symptoms and, where relevant, discuss how they may be potentially treated. The book addresses most of the known symptoms that occur in patients with Parkinson's disease. In addition to the classic motor triad, motor speech, eye movements, olfactory dysfunction, autonomic dysfunction, pain and sensory abnormalities, sleep disturbances, depression and apathy, dopamine dysregulation syndromes, hallucinations and psychoses, cognitive impairment and dementia, and systemic manifestations are all reviewed. Early selective cell loss in non-dopaminergic regions is highlighted (the glutamate projection neurons of the presupplementary motor cortex and caudal intralaminar thalamus) in addition to the widespread inclusion formation in many regions outside the basal ganglia that characterize the disease. Overall this book provides a comprehensive analysis of the lesions associated with the most common symptoms found in patients with Parkinson's disease.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Parkinson's disease becomes apparent only after substantial loss (>60%) of the dopamine neurons in the substantia nigra. By this time there has already been widespread neural inclusion formation in the peripheral and central nervous system of patients with the disease, although this has only been recognized more recently. Degeneration in these widespread regions of the peripheral and central nervous system is now known to impact on disease symptoms, progression and treatment over time. This book aims to provide a comprehensive review of these non-dopamine lesions in Parkinson's disease by assessing our current knowledge of their presence and pathophysiology, how they relate to different symptoms and, where relevant, discuss how they may be potentially treated. The book addresses most of the known symptoms that occur in patients with Parkinson's disease. In addition to the classic motor triad, motor speech, eye movements, olfactory dysfunction, autonomic dysfunction, pain and sensory abnormalities, sleep disturbances, depression and apathy, dopamine dysregulation syndromes, hallucinations and psychoses, cognitive impairment and dementia, and systemic manifestations are all reviewed. Early selective cell loss in non-dopaminergic regions is highlighted (the glutamate projection neurons of the presupplementary motor cortex and caudal intralaminar thalamus) in addition to the widespread inclusion formation in many regions outside the basal ganglia that characterize the disease. Overall this book provides a comprehensive analysis of the lesions associated with the most common symptoms found in patients with Parkinson's disease.

More books from Oxford University Press

Cover of the book Why Some Firms Thrive While Others Fail by
Cover of the book Musical Symbolism in the Operas of Debussy and Bartok by
Cover of the book Insanity by
Cover of the book Slavery and Class in the American South by
Cover of the book Heart of Buddha, Heart of China by
Cover of the book In the Shade of the Golden Palace by
Cover of the book The Elusive Dream by
Cover of the book Cognitive-Behavioral Therapy for Social Phobia in Adolescents by
Cover of the book Responsible Conduct of Research by
Cover of the book The Will to Punish by
Cover of the book Except When I Write by
Cover of the book Gilbert and Sullivan by
Cover of the book Guns and Suicide by
Cover of the book Composing the World by
Cover of the book The Big Muddy by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy