Malignant Tumors in Organ Transplant Recipients

Nonfiction, Health & Well Being, Medical
Cover of the book Malignant Tumors in Organ Transplant Recipients by Israel Penn, Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Israel Penn ISBN: 9783642462559
Publisher: Springer Berlin Heidelberg Publication: December 6, 2012
Imprint: Springer Language: English
Author: Israel Penn
ISBN: 9783642462559
Publisher: Springer Berlin Heidelberg
Publication: December 6, 2012
Imprint: Springer
Language: English

There is a great deal of experimental work leading to the conclusion that immuno­ suppression of any kind increases susceptibility to clinical or viral carcinogenesis. Human epidemiology had already given some intimation of the abnormally high incidence of neoplasms in persons suffering from immunologic insufficiency. The first statistics on the incidence of cancer in organ transplant recipients tend to support this thesis. Transplantation can favor metastasis in a recipient who already has a malignancy; similarly, it can encourage the development of tumor cells which may be present in an organ transplanted from a cancerous donor; and finally, the frequency of lymphomas and carcinomas is higher in transplant recipients than in the general population. Immunodepression induced to facilitate tolerance clearly falls under suspicion on the basis of the experimental and clinical findings mentioned above. Anti-lymphocyte serum is not the only suspect-tumors have also occurred in patients treated with prednisone and Imuran alone. Now comes Dr. PENN'S monograph with a detailed account of these phenomena, together with an analysis and discussion. Clearly, induced carcinogenesis in man must be taken seriously. Not only must every precaution be taken in the screening of donor and recipient and the choice of immunosuppressive therapy in order to reduce it to the minimum, there is also the question whether the long-term immunosuppressive treatments inflicted upon patients in whom an auto-immune mechanism is thought to be the cause of the disease-treat­ ments whose efficacy is even more questionable than the mechanism-might not themselves be contributing to malignancy.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

There is a great deal of experimental work leading to the conclusion that immuno­ suppression of any kind increases susceptibility to clinical or viral carcinogenesis. Human epidemiology had already given some intimation of the abnormally high incidence of neoplasms in persons suffering from immunologic insufficiency. The first statistics on the incidence of cancer in organ transplant recipients tend to support this thesis. Transplantation can favor metastasis in a recipient who already has a malignancy; similarly, it can encourage the development of tumor cells which may be present in an organ transplanted from a cancerous donor; and finally, the frequency of lymphomas and carcinomas is higher in transplant recipients than in the general population. Immunodepression induced to facilitate tolerance clearly falls under suspicion on the basis of the experimental and clinical findings mentioned above. Anti-lymphocyte serum is not the only suspect-tumors have also occurred in patients treated with prednisone and Imuran alone. Now comes Dr. PENN'S monograph with a detailed account of these phenomena, together with an analysis and discussion. Clearly, induced carcinogenesis in man must be taken seriously. Not only must every precaution be taken in the screening of donor and recipient and the choice of immunosuppressive therapy in order to reduce it to the minimum, there is also the question whether the long-term immunosuppressive treatments inflicted upon patients in whom an auto-immune mechanism is thought to be the cause of the disease-treat­ ments whose efficacy is even more questionable than the mechanism-might not themselves be contributing to malignancy.

More books from Springer Berlin Heidelberg

Cover of the book Quantum Physics by Israel Penn
Cover of the book The Role of Oxidative Stress in Neuronal Death by Israel Penn
Cover of the book A Concise Guide to Endodontic Procedures by Israel Penn
Cover of the book Manual on the AO/ASIF Tubular External Fixator by Israel Penn
Cover of the book Empirische Ökonomie by Israel Penn
Cover of the book Topological Galois Theory by Israel Penn
Cover of the book Physik unserer Umwelt: Die Atmosphäre by Israel Penn
Cover of the book Modality, Semantics and Interpretations by Israel Penn
Cover of the book Setting Up Wholly Foreign Owned Enterprises in China by Israel Penn
Cover of the book Das Heureka-Prinzip by Israel Penn
Cover of the book Hydrogen Bonded Supramolecular Structures by Israel Penn
Cover of the book The Histogenesis of the Spinal Ganglia by Israel Penn
Cover of the book Verification and Validation in Systems Engineering by Israel Penn
Cover of the book Earth System Modelling - Volume 4 by Israel Penn
Cover of the book New Findings on Aclarubicin in the Treatment of Acute Myeloid Leukemia by Israel Penn
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy