Male-Mediated Developmental Toxicity

Nonfiction, Health & Well Being, Medical, Medical Science, Pharmacology, Science & Nature, Science, Biological Sciences
Cover of the book Male-Mediated Developmental Toxicity by , Springer US
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781461518778
Publisher: Springer US Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9781461518778
Publisher: Springer US
Publication: December 6, 2012
Imprint: Springer
Language: English

The cause of many of the adverse reproductive outcomes and developmental diseases among offspring is not well understood. Most of the epidemiologic and experimental animal research has focused on the relationship between maternal exposures including medications, tobacco smoke, alcohol, infections, and occupation and the occurrence of spontaneous abortion, low birth weight, and birth defects. The potential role of paternal exposures has not been investigated as extensively despite long-standing animal research that demonstrates the induction of mutations in the male germ cell after exposure to certain agents and subsequent reproductive failure or early pregnancy loss. Given this relative lack of interest, acquisition of epidemiologic data and the development of a definitive model or mechanism for potential male-mediated effects has been hindered. However, recent laboratory and epidemiologic investigations have suggested that paternal exposures may be more important than previously suspected. This topic has been termed by some as "male-mediated developmental toxicity. " This is meant to refer to the effects of exposures and other factors relating to the male parent that result in toxicity to the conceptus and abnormal development. The developmental endpoints of interest can include fetal loss, congenital abnormalities, growth retardation, cancer, and neurobehavioral effects. These effects may operate through a variety of mechanisms including gene mutation, chromosomal aberrations, seminal fluid transfer of toxicants and epigenetic events.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The cause of many of the adverse reproductive outcomes and developmental diseases among offspring is not well understood. Most of the epidemiologic and experimental animal research has focused on the relationship between maternal exposures including medications, tobacco smoke, alcohol, infections, and occupation and the occurrence of spontaneous abortion, low birth weight, and birth defects. The potential role of paternal exposures has not been investigated as extensively despite long-standing animal research that demonstrates the induction of mutations in the male germ cell after exposure to certain agents and subsequent reproductive failure or early pregnancy loss. Given this relative lack of interest, acquisition of epidemiologic data and the development of a definitive model or mechanism for potential male-mediated effects has been hindered. However, recent laboratory and epidemiologic investigations have suggested that paternal exposures may be more important than previously suspected. This topic has been termed by some as "male-mediated developmental toxicity. " This is meant to refer to the effects of exposures and other factors relating to the male parent that result in toxicity to the conceptus and abnormal development. The developmental endpoints of interest can include fetal loss, congenital abnormalities, growth retardation, cancer, and neurobehavioral effects. These effects may operate through a variety of mechanisms including gene mutation, chromosomal aberrations, seminal fluid transfer of toxicants and epigenetic events.

More books from Springer US

Cover of the book Research in Photobiology by
Cover of the book Hybrid Nanocomposites for Nanotechnology by
Cover of the book Race and the Jury by
Cover of the book Sociocultural Roots of Mental Illness by
Cover of the book Myelin Repair and Neuroprotection in Multiple Sclerosis by
Cover of the book Designing Stress Resistant Organizations by
Cover of the book Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury by
Cover of the book Defining Prevention Science by
Cover of the book The Causal Structure of Long-Term Supply Relationships by
Cover of the book Cardiomyopathies and Heart Failure by
Cover of the book Careful Economics by
Cover of the book Effective Communication Skills for Health Professionals by
Cover of the book Empirical Studies of Environmental Policies in Europe by
Cover of the book Advances in Information Systems Science by
Cover of the book Children’s Competence to Consent by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy