Malaria Vaccines

The Continuing Quest

In 2013, 200 million people were infected with malaria, resulting in over 584,000 deaths, with the potential to affect over half the world's population. Such is the widespread nature of malaria that it is increasingly believed only a vaccine will lead to its eradication.

Although the first attempt at a vaccine was made a century ago, it is only in the last 30 years that real progress in testing has been made, in the hope of discovering a molecule that can provide long-lasting protection against the disease. In July 2015, GlaxoSmithKline (GSK) announced that after 30 years of research it had received the green light from the European Medicines Agency for the world's first malaria vaccine, RTS, S, for use in African children aged 6 weeks to 17 months.

This book chronicles the development of RTS, S — done in collaboration with the Walter Reed Army Institute for Research, the PATH Malaria Vaccine Initiative (MVI) and funded in part by the Bill and Melinda Gates Foundation — as well as previous candidate vaccines. It also focusses on the continuing quest to find more effective vaccines against this continuing health crisis. Finally, it provides an easily understood background on recombinant DNA and monoclonal antibodies and places them in perspective to their contributions to malaria vaccine development.

This book serves as a convenient and easily accessible source of information for students, teachers, microbiologists, parasitologists, physicians, clinicians and research funders.

Contents:

• The Three Lives of the Malaria Parasite
• A Personal Scientific Odyssey
• Taming the Malaria Parasite
• The Quest for a Blood Stage Vaccine Begins
• Malaria Vaccines and Malfeasance
• Dreaming of a Nobel Prize
• Molecular Biology Assists in Vaccine Development
• Developing Vaccines Against Blood Stages
• PfEMP1, pfalhesin, and DBR
• Vaccines to Halt Transmission
• Sporozoite Invasion and the Path to RTS, S
• Attenuated Plasmodial Vaccines
• Viruses and Plasmodial Vaccines
• Why the Quest Continues

Readership: Graduate students, teachers, microbiologists, parasitologists, physicians, clinicians, funders of research and readers interested in the research area.
Key Features:

• Provides an easily understood background on recombinant DNA and monoclonal antibodies and places them in perspective to their contributions to malaria vaccine development
• Provides an up-to-date account of developments and insight into the creative scientific process
• Short biographical sketches tell the value of the contributions made by numerous investigators including the author
• Celebrates the successes and failure and places the reasons for optimism (or pessimism) in perspective