Iron Acquisition by the Genus Mycobacterium

History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development

Nonfiction, Science & Nature, Science, Biological Sciences, Biochemistry, Microbiology
Cover of the book Iron Acquisition by the Genus Mycobacterium by , Springer International Publishing
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Author: ISBN: 9783319003030
Publisher: Springer International Publishing Publication: May 17, 2013
Imprint: Springer Language: English
Author:
ISBN: 9783319003030
Publisher: Springer International Publishing
Publication: May 17, 2013
Imprint: Springer
Language: English

Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described.  The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed.  The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.

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Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described.  The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed.  The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.

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