Immunopharmacology

Nonfiction, Health & Well Being, Medical, Medical Science, Immunology, Pharmacology
Cover of the book Immunopharmacology by Manzoor M. Khan, Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Manzoor M. Khan ISBN: 9783319302737
Publisher: Springer International Publishing Publication: June 21, 2016
Imprint: Springer Language: English
Author: Manzoor M. Khan
ISBN: 9783319302737
Publisher: Springer International Publishing
Publication: June 21, 2016
Imprint: Springer
Language: English

The concept of immunotherapy was in infancy when the first edition was written; since then, major advances have been made, not only with several prominent clinical trials, but also with the approval of cell-based therapy by the FDA for the treatment of cancer in 2010.  These events resulted in a gradually narrowing gap between early scientific knowledge and the late development of immune-based therapies. Consequently, the significance and magnitude of these advances warranted a revision of this contribution; this revised edition will provide a deeper understanding of the recent advances and discoveries related to the function of the immune response and their applications in the development of novel therapies to treat human diseases. Some of the key discoveries during the past five years include: the identification of the new subsets of helper T cells; new cytokines and their networks; and novel signal transduction mechanisms. For example, the identification of TH17 subset of helper T cells, in addition to TH1 and TH2 cells, not only advanced our understanding of the function of the basic immune response, but also raised our awareness of the possible etiology and pathogenesis of diseases such as allergy, asthma, rheumatoid arthritis, and other auto-immune/immune system based diseases. The newly identified powerful cytokine networks, that regulate both innate and acquired immune responses, emerged as a result of the finding of new cell types such as innate lymphoid cells and iNKT.  Identification of the novel cytokines and their networks has advanced our knowledge of the mechanisms involved in the maintenance of tissue homeostasis, including inflammation and tissue repair during stress and injury. The development of HIV vaccines has also seen dramatic changes over the last few years. There has been a shift from a sole focus on T cell vaccines to a holistic approach that pertains to the induction of both humoral and cellular elements. This entails the induction of antibodies – both binding and neutralizing – to prevent infection. The cellular vaccination produces a safety net of CD8+ T-cell responses to suppress the replication of the virus in the infected patients, and both of the effector arms are aided by helper T cells.  From the perspective of clinical applications, significant advances have also been made in: oral immunotherapy for allergic disease, the possible treatment of HIV infection, the development of new monoclonal antibodies and their fragments to treat human diseases, and immune cell based therapies for cancer. 

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The concept of immunotherapy was in infancy when the first edition was written; since then, major advances have been made, not only with several prominent clinical trials, but also with the approval of cell-based therapy by the FDA for the treatment of cancer in 2010.  These events resulted in a gradually narrowing gap between early scientific knowledge and the late development of immune-based therapies. Consequently, the significance and magnitude of these advances warranted a revision of this contribution; this revised edition will provide a deeper understanding of the recent advances and discoveries related to the function of the immune response and their applications in the development of novel therapies to treat human diseases. Some of the key discoveries during the past five years include: the identification of the new subsets of helper T cells; new cytokines and their networks; and novel signal transduction mechanisms. For example, the identification of TH17 subset of helper T cells, in addition to TH1 and TH2 cells, not only advanced our understanding of the function of the basic immune response, but also raised our awareness of the possible etiology and pathogenesis of diseases such as allergy, asthma, rheumatoid arthritis, and other auto-immune/immune system based diseases. The newly identified powerful cytokine networks, that regulate both innate and acquired immune responses, emerged as a result of the finding of new cell types such as innate lymphoid cells and iNKT.  Identification of the novel cytokines and their networks has advanced our knowledge of the mechanisms involved in the maintenance of tissue homeostasis, including inflammation and tissue repair during stress and injury. The development of HIV vaccines has also seen dramatic changes over the last few years. There has been a shift from a sole focus on T cell vaccines to a holistic approach that pertains to the induction of both humoral and cellular elements. This entails the induction of antibodies – both binding and neutralizing – to prevent infection. The cellular vaccination produces a safety net of CD8+ T-cell responses to suppress the replication of the virus in the infected patients, and both of the effector arms are aided by helper T cells.  From the perspective of clinical applications, significant advances have also been made in: oral immunotherapy for allergic disease, the possible treatment of HIV infection, the development of new monoclonal antibodies and their fragments to treat human diseases, and immune cell based therapies for cancer. 

More books from Springer International Publishing

Cover of the book Intelligent Systems Design and Applications by Manzoor M. Khan
Cover of the book Advances in The Human Side of Service Engineering by Manzoor M. Khan
Cover of the book Combatting Jihadist Terrorism through Nation-Building by Manzoor M. Khan
Cover of the book Peace Research and Peacebuilding by Manzoor M. Khan
Cover of the book From Astrophysics to Unconventional Computation by Manzoor M. Khan
Cover of the book Performance Evaluation and Benchmarking: Traditional to Big Data to Internet of Things by Manzoor M. Khan
Cover of the book Alkaptonuria and Ochronosis by Manzoor M. Khan
Cover of the book Ketamine for Treatment-Resistant Depression by Manzoor M. Khan
Cover of the book Extended Abstracts Spring 2014 by Manzoor M. Khan
Cover of the book High Temperature Polymer Electrolyte Membrane Fuel Cells by Manzoor M. Khan
Cover of the book Formal Methods and Software Engineering by Manzoor M. Khan
Cover of the book Background Processes in the Electrostatic Spectrometers of the KATRIN Experiment by Manzoor M. Khan
Cover of the book Lightweight Cryptography for Security and Privacy by Manzoor M. Khan
Cover of the book Science and the Economic Crisis by Manzoor M. Khan
Cover of the book Service Research and Innovation by Manzoor M. Khan
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy