Hyaluronan in Cancer Biology

Nonfiction, Health & Well Being, Medical, Specialties, Oncology, Science & Nature, Science
Cover of the book Hyaluronan in Cancer Biology by , Elsevier Science
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9780080921082
Publisher: Elsevier Science Publication: March 7, 2009
Imprint: Academic Press Language: English
Author:
ISBN: 9780080921082
Publisher: Elsevier Science
Publication: March 7, 2009
Imprint: Academic Press
Language: English

Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal.

The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book will offer a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer.

  • Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer
  • Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination
  • Focuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal.

The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book will offer a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer.

More books from Elsevier Science

Cover of the book Digital Signal Processing: Instant Access by
Cover of the book America Invents Act Primer by
Cover of the book Intelligent Speech Signal Processing by
Cover of the book Development of Packaging and Products for Use in Microwave Ovens by
Cover of the book Quantitation of Amino Acids and Amines by Chromatography by
Cover of the book Interpreting Biomedical Science by
Cover of the book RNA Methodologies by
Cover of the book Integrating the Neurobiology of Schizophrenia by
Cover of the book Agro-Industrial Wastes as Feedstock for Enzyme Production by
Cover of the book Semiconductor Lasers by
Cover of the book Food Bioconversion by
Cover of the book Vitamin E by
Cover of the book Coral Reef Marine Plants of Hainan Island by
Cover of the book A Fractal Analysis of Chemical Kinetics with Applications to Biological and Biosensor Interfaces by
Cover of the book Applied Drilling Circulation Systems by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy