Enzyme-Prodrug Strategies for Cancer Therapy

Nonfiction, Health & Well Being, Medical, Specialties, Oncology, Internal Medicine, General
Cover of the book Enzyme-Prodrug Strategies for Cancer Therapy by , Springer US
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781461548232
Publisher: Springer US Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9781461548232
Publisher: Springer US
Publication: December 6, 2012
Imprint: Springer
Language: English

Antibody-directed enzyme prodrug therapy (ADEPT) directly addresses the major problem in cancer chemotherapy-its lack of selectivity. Antibody delivery combined with the amplification provided by the enzymatic activation of prodrugs enables selection to be made between tumour and normal tissue. ADEPT offers a novel field of opportunities in the therapy of systemic cancer and may be a major advance for the treatment of solid tumours.
This book is the first to describe ADEPT in detail. Each chapter reviews an aspect of the immunology, enzymology, biochemistry, chemistry, and cancer chemotherapy which have been integrated into the ADEPT concept. An additional chapter describes the related approach of gene-directed enzyme prodrug therapy (GDEPT). This latter approach is still in its infancy but ADEPT has entered the clinic. The initial clinical studies with ADEPT are included and discussed in detail.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Antibody-directed enzyme prodrug therapy (ADEPT) directly addresses the major problem in cancer chemotherapy-its lack of selectivity. Antibody delivery combined with the amplification provided by the enzymatic activation of prodrugs enables selection to be made between tumour and normal tissue. ADEPT offers a novel field of opportunities in the therapy of systemic cancer and may be a major advance for the treatment of solid tumours.
This book is the first to describe ADEPT in detail. Each chapter reviews an aspect of the immunology, enzymology, biochemistry, chemistry, and cancer chemotherapy which have been integrated into the ADEPT concept. An additional chapter describes the related approach of gene-directed enzyme prodrug therapy (GDEPT). This latter approach is still in its infancy but ADEPT has entered the clinic. The initial clinical studies with ADEPT are included and discussed in detail.

More books from Springer US

Cover of the book Hurricanes and Climate Change by
Cover of the book The Lactic Acid Bacteria:Volume 1 by
Cover of the book Bacterial Infections of Humans by
Cover of the book Advances in Clinical Child Psychology by
Cover of the book Architecture and Design of Distributed Embedded Systems by
Cover of the book Breast Cancer: Cellular and Molecular Biology by
Cover of the book Neutron Imaging and Applications by
Cover of the book Influenza by
Cover of the book Basic Functions of Language, Reading and Reading Disability by
Cover of the book The Genetics of Cardiovascular Disease by
Cover of the book Keyboard, Graphic and Handwriting Skills by
Cover of the book Problem Solving in Business and Management by
Cover of the book Routing and Quality-of-Service in Broadband LEO Satellite Networks by
Cover of the book Comprehensive Handbook of Cognitive Therapy by
Cover of the book Relational Frame Theory by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy